Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

Tomohiko Asada; Minoru Iwata; Shigeru Matsuzaki; Hiroshi Hamakawa; Satoru Sengan; Toshifumi Noguchi; Kazushi Daimon; Naoki Matsumura; Morikazu Shibasaki; Tetsushi Tsujimoto; Ken Ooi; Hidenao Fukuyama

doi:10.1016/j.jecr.2022.100107

Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

Tomohiko Asada^*, Minoru Iwata, Shigeru Matsuzaki, Hiroshi Hamakawa, Satoru Sengan, Toshifumi Noguchi, Kazushi Daimon, Naoki Matsumura, Morikazu Shibasaki, Tetsushi Tsujimoto, Ken Ooi, Hidenao Fukuyama

^*Corresponding author for this work

Human Science 2

Research output: Contribution to journal › Article › peer-review

Abstract

We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) ₂ vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) ₂ vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.

Original language	English
Article number	100107
Journal	Journal of Clinical and Translational Endocrinology: Case Reports
Volume	23
DOIs	https://doi.org/10.1016/j.jecr.2022.100107
State	Published - 2022/03

Keywords

25-OH vitamin D deficiency
Alcoholic liver damage
Alcoholic patient
Excessive renal reabsorption
Hypercalcemia with hyperphosphatemia
Normal renal function

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jecr.2022.100107

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Asada, T., Iwata, M., Matsuzaki, S., Hamakawa, H., Sengan, S., Noguchi, T., Daimon, K., Matsumura, N., Shibasaki, M., Tsujimoto, T., Ooi, K., & Fukuyama, H. (2022). Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function. Journal of Clinical and Translational Endocrinology: Case Reports, 23, Article 100107. https://doi.org/10.1016/j.jecr.2022.100107

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title = "Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function",

abstract = "We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) 2 vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) 2 vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.",

keywords = "25-OH vitamin D deficiency, Alcoholic liver damage, Alcoholic patient, Excessive renal reabsorption, Hypercalcemia with hyperphosphatemia, Normal renal function",

author = "Tomohiko Asada and Minoru Iwata and Shigeru Matsuzaki and Hiroshi Hamakawa and Satoru Sengan and Toshifumi Noguchi and Kazushi Daimon and Naoki Matsumura and Morikazu Shibasaki and Tetsushi Tsujimoto and Ken Ooi and Hidenao Fukuyama",

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year = "2022",

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doi = "10.1016/j.jecr.2022.100107",

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Asada, T, Iwata, M, Matsuzaki, S, Hamakawa, H, Sengan, S, Noguchi, T, Daimon, K, Matsumura, N, Shibasaki, M, Tsujimoto, T, Ooi, K & Fukuyama, H 2022, 'Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function', Journal of Clinical and Translational Endocrinology: Case Reports, vol. 23, 100107. https://doi.org/10.1016/j.jecr.2022.100107

TY - JOUR

T1 - Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

AU - Asada, Tomohiko

AU - Iwata, Minoru

AU - Matsuzaki, Shigeru

AU - Hamakawa, Hiroshi

AU - Sengan, Satoru

AU - Noguchi, Toshifumi

AU - Daimon, Kazushi

AU - Matsumura, Naoki

AU - Shibasaki, Morikazu

AU - Tsujimoto, Tetsushi

AU - Ooi, Ken

AU - Fukuyama, Hidenao

PY - 2022/3

Y1 - 2022/3

N2 - We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) 2 vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) 2 vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.

AB - We present the case of a 55-year-old female patient with alcohol-related liver damage who presented with hypercalcemia and hyperphosphatemia but also showed severe paradoxical reduction in serum 25-OH vitamin D levels. The serum levels of 1, 25-(OH) 2 vitamin D, parathyroid hormone, and renal function parameters were normal. Therefore, we examined the renal reabsorption of calcium and phosphate and found a mild increase in both. The serum levels of calcium and phosphate might be determined by 1, 25-(OH) 2 vitamin D-mediated excessive renal reabsorption of calcium and phosphate in alcoholics with 25-OH vitamin D deficiency but normal renal function.

KW - 25-OH vitamin D deficiency

KW - Alcoholic liver damage

KW - Alcoholic patient

KW - Excessive renal reabsorption

KW - Hypercalcemia with hyperphosphatemia

KW - Normal renal function

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U2 - 10.1016/j.jecr.2022.100107

DO - 10.1016/j.jecr.2022.100107

M3 - 学術論文

AN - SCOPUS:85123006382

SN - 2214-6245

VL - 23

JO - Journal of Clinical and Translational Endocrinology: Case Reports

JF - Journal of Clinical and Translational Endocrinology: Case Reports

M1 - 100107

ER -

Hypercalcemia and hyperphosphatemia associated with 25-OH vitamin D deficiency in an alcoholic patient with normal renal function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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