TY - JOUR
T1 - Heschl’s Gyrus Duplication Pattern in Individuals at Risk of Developing Psychosis and Patients With Schizophrenia
AU - Takahashi, Tsutomu
AU - Sasabayashi, Daiki
AU - Takayanagi, Yoichiro
AU - Higuchi, Yuko
AU - Mizukami, Yuko
AU - Nishiyama, Shimako
AU - Furuichi, Atsushi
AU - Kido, Mikio
AU - Pham, Tien Viet
AU - Kobayashi, Haruko
AU - Noguchi, Kyo
AU - Suzuki, Michio
N1 - Publisher Copyright:
© Copyright © 2021 Takahashi, Sasabayashi, Takayanagi, Higuchi, Mizukami, Nishiyama, Furuichi, Kido, Pham, Kobayashi, Noguchi and Suzuki.
PY - 2021/4/20
Y1 - 2021/4/20
N2 - An increased prevalence of duplicated Heschl’s gyrus (HG), which may reflect an early neurodevelopmental pathology, has been reported in schizophrenia (Sz). However, it currently remains unclear whether individuals at risk of psychosis exhibit similar brain morphological characteristics. This magnetic resonance imaging study investigated the distribution of HG gyrification patterns [i.e., single HG, common stem duplication (CSD), and complete posterior duplication (CPD)] and their relationship with clinical characteristics in 57 individuals with an at-risk mental state (ARMS) [of whom 5 (8.8%) later developed Sz], 63 patients with Sz, and 61 healthy comparisons. The prevalence of duplicated HG patterns (i.e., CSD or CPD) bilaterally was significantly higher in the ARMS and Sz groups than in the controls, whereas no significant differences were observed in HG patterns between these groups. The left CSD pattern, particularly in the Sz group, was associated with a verbal fluency deficit. In the ARMS group, left CSD pattern was related to a more severe general psychopathology. The present results suggest that an altered gyrification pattern on the superior temporal plane reflects vulnerability factors associated with Sz, which may also contribute to the clinical features of high-risk individuals, even without the onset of psychosis.
AB - An increased prevalence of duplicated Heschl’s gyrus (HG), which may reflect an early neurodevelopmental pathology, has been reported in schizophrenia (Sz). However, it currently remains unclear whether individuals at risk of psychosis exhibit similar brain morphological characteristics. This magnetic resonance imaging study investigated the distribution of HG gyrification patterns [i.e., single HG, common stem duplication (CSD), and complete posterior duplication (CPD)] and their relationship with clinical characteristics in 57 individuals with an at-risk mental state (ARMS) [of whom 5 (8.8%) later developed Sz], 63 patients with Sz, and 61 healthy comparisons. The prevalence of duplicated HG patterns (i.e., CSD or CPD) bilaterally was significantly higher in the ARMS and Sz groups than in the controls, whereas no significant differences were observed in HG patterns between these groups. The left CSD pattern, particularly in the Sz group, was associated with a verbal fluency deficit. In the ARMS group, left CSD pattern was related to a more severe general psychopathology. The present results suggest that an altered gyrification pattern on the superior temporal plane reflects vulnerability factors associated with Sz, which may also contribute to the clinical features of high-risk individuals, even without the onset of psychosis.
KW - Heschl’s gyrus
KW - at-risk mental state
KW - early neurodevelopment
KW - gyrification
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85105139096&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2021.647069
DO - 10.3389/fnbeh.2021.647069
M3 - 学術論文
C2 - 33958991
AN - SCOPUS:85105139096
SN - 1662-5153
VL - 15
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
M1 - 647069
ER -