Glucokinase maturity-onset diabetes of the young as a mimicker of stress hyperglycemia: a case report

Yoshitaka Nakasato, Shintaro Terashita*, Shohei Kusabiraki, Sadashi Horie, Takuya Wada, Motokazu Nakabayashi, Megumi Nakamura, Tohru Yorifuji

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from stress hyperglycemia. Following the development of febrile seizures owing to adenovirus infection, the patient presented a casual blood glucose level was 185 mg/dL. She had a multigenerational family history of diabetes and a hemoglobin A1c (HbA1c) level of 6.4%. Owing to the persistent glucose intolerance until the age of 5 years, genetic testing was performed, which revealed a heterozygous mutation in GCK, and the patient was diagnosed with GCK-MODY. Precise diagnosis of GCK-MODY individuals is important to avoid administering unnecessary antidiabetic medications. Even during hyperglycemia under stress, multigenerational diabetes and mildly elevated HbA1c levels can suggest GCK-MODY.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalClinical Pediatric Endocrinology
Volume32
Issue number1
DOIs
StatePublished - 2023

Keywords

  • glucokinase
  • maturity-onset diabetes of the young
  • stress hyperglycemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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