TY - JOUR
T1 - Glucokinase maturity-onset diabetes of the young as a mimicker of stress hyperglycemia
T2 - a case report
AU - Nakasato, Yoshitaka
AU - Terashita, Shintaro
AU - Kusabiraki, Shohei
AU - Horie, Sadashi
AU - Wada, Takuya
AU - Nakabayashi, Motokazu
AU - Nakamura, Megumi
AU - Yorifuji, Tohru
N1 - Publisher Copyright:
© 2023 by The Japanese Society for Pediatric Endocrinology.
PY - 2023
Y1 - 2023
N2 - Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from stress hyperglycemia. Following the development of febrile seizures owing to adenovirus infection, the patient presented a casual blood glucose level was 185 mg/dL. She had a multigenerational family history of diabetes and a hemoglobin A1c (HbA1c) level of 6.4%. Owing to the persistent glucose intolerance until the age of 5 years, genetic testing was performed, which revealed a heterozygous mutation in GCK, and the patient was diagnosed with GCK-MODY. Precise diagnosis of GCK-MODY individuals is important to avoid administering unnecessary antidiabetic medications. Even during hyperglycemia under stress, multigenerational diabetes and mildly elevated HbA1c levels can suggest GCK-MODY.
AB - Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from stress hyperglycemia. Following the development of febrile seizures owing to adenovirus infection, the patient presented a casual blood glucose level was 185 mg/dL. She had a multigenerational family history of diabetes and a hemoglobin A1c (HbA1c) level of 6.4%. Owing to the persistent glucose intolerance until the age of 5 years, genetic testing was performed, which revealed a heterozygous mutation in GCK, and the patient was diagnosed with GCK-MODY. Precise diagnosis of GCK-MODY individuals is important to avoid administering unnecessary antidiabetic medications. Even during hyperglycemia under stress, multigenerational diabetes and mildly elevated HbA1c levels can suggest GCK-MODY.
KW - glucokinase
KW - maturity-onset diabetes of the young
KW - stress hyperglycemia
UR - http://www.scopus.com/inward/record.url?scp=85147170870&partnerID=8YFLogxK
U2 - 10.1297/cpe.2022-0024
DO - 10.1297/cpe.2022-0024
M3 - 学術論文
C2 - 36761491
AN - SCOPUS:85147170870
SN - 0918-5739
VL - 32
SP - 72
EP - 75
JO - Clinical Pediatric Endocrinology
JF - Clinical Pediatric Endocrinology
IS - 1
ER -