GABAergic mechanisms in the action of general anesthetics

K. Hirota; S. H. Roth; J. Fujimura; A. Masuda; Y. Ito

doi:10.1016/S0378-4274(98)00186-6

GABAergic mechanisms in the action of general anesthetics

K. Hirota^*, S. H. Roth, J. Fujimura, A. Masuda, Y. Ito

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

1. The effects of volatile and intravenous anesthetics were studied on evoked field potentials in rat hippocampal CA1 neurons in vitro to determine the role of GABAergic mechanisms in the action of general anesthetics. 2. It was observed that both volatile (halothane, isoflurane, sevoflurane) and intravenous (thiopental, pentobarbital, propofol) anesthetics decreased population spike (PS) amplitudes. 3. Using paired-pulse paradigms, it was revealed that volatile agents enhance paired-pulse facilitation (PPF), and intravenous agents reduce PPF. Use-dependent effects on PS amplitudes were observed following application of the intravenous anesthetics, whereas volatile agents did not show use-dependency. The effects of the intravenous anesthetics were blocked by the GABA(A) receptor antagonist, bicuculline. 4. It is suggested that agent specific actions of general anesthetics are a result of differential effects on GABAergic mechanisms that modulate synaptic transmission. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Toxicology Letters
Volume	100-101
DOIs	https://doi.org/10.1016/S0378-4274(98)00186-6
State	Published - 1998/11/23

Keywords

Agent specific action
General anesthetics
Population spike
Rat hippocampal slice

ASJC Scopus subject areas

Toxicology

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10.1016/S0378-4274(98)00186-6

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title = "GABAergic mechanisms in the action of general anesthetics",

abstract = "1. The effects of volatile and intravenous anesthetics were studied on evoked field potentials in rat hippocampal CA1 neurons in vitro to determine the role of GABAergic mechanisms in the action of general anesthetics. 2. It was observed that both volatile (halothane, isoflurane, sevoflurane) and intravenous (thiopental, pentobarbital, propofol) anesthetics decreased population spike (PS) amplitudes. 3. Using paired-pulse paradigms, it was revealed that volatile agents enhance paired-pulse facilitation (PPF), and intravenous agents reduce PPF. Use-dependent effects on PS amplitudes were observed following application of the intravenous anesthetics, whereas volatile agents did not show use-dependency. The effects of the intravenous anesthetics were blocked by the GABA(A) receptor antagonist, bicuculline. 4. It is suggested that agent specific actions of general anesthetics are a result of differential effects on GABAergic mechanisms that modulate synaptic transmission. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

keywords = "Agent specific action, General anesthetics, Population spike, Rat hippocampal slice",

author = "K. Hirota and Roth, {S. H.} and J. Fujimura and A. Masuda and Y. Ito",

year = "1998",

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day = "23",

doi = "10.1016/S0378-4274(98)00186-6",

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T1 - GABAergic mechanisms in the action of general anesthetics

AU - Hirota, K.

AU - Roth, S. H.

AU - Fujimura, J.

AU - Masuda, A.

AU - Ito, Y.

PY - 1998/11/23

Y1 - 1998/11/23

N2 - 1. The effects of volatile and intravenous anesthetics were studied on evoked field potentials in rat hippocampal CA1 neurons in vitro to determine the role of GABAergic mechanisms in the action of general anesthetics. 2. It was observed that both volatile (halothane, isoflurane, sevoflurane) and intravenous (thiopental, pentobarbital, propofol) anesthetics decreased population spike (PS) amplitudes. 3. Using paired-pulse paradigms, it was revealed that volatile agents enhance paired-pulse facilitation (PPF), and intravenous agents reduce PPF. Use-dependent effects on PS amplitudes were observed following application of the intravenous anesthetics, whereas volatile agents did not show use-dependency. The effects of the intravenous anesthetics were blocked by the GABA(A) receptor antagonist, bicuculline. 4. It is suggested that agent specific actions of general anesthetics are a result of differential effects on GABAergic mechanisms that modulate synaptic transmission. Copyright (C) 1998 Elsevier Science Ireland Ltd.

AB - 1. The effects of volatile and intravenous anesthetics were studied on evoked field potentials in rat hippocampal CA1 neurons in vitro to determine the role of GABAergic mechanisms in the action of general anesthetics. 2. It was observed that both volatile (halothane, isoflurane, sevoflurane) and intravenous (thiopental, pentobarbital, propofol) anesthetics decreased population spike (PS) amplitudes. 3. Using paired-pulse paradigms, it was revealed that volatile agents enhance paired-pulse facilitation (PPF), and intravenous agents reduce PPF. Use-dependent effects on PS amplitudes were observed following application of the intravenous anesthetics, whereas volatile agents did not show use-dependency. The effects of the intravenous anesthetics were blocked by the GABA(A) receptor antagonist, bicuculline. 4. It is suggested that agent specific actions of general anesthetics are a result of differential effects on GABAergic mechanisms that modulate synaptic transmission. Copyright (C) 1998 Elsevier Science Ireland Ltd.

KW - Agent specific action

KW - General anesthetics

KW - Population spike

KW - Rat hippocampal slice

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U2 - 10.1016/S0378-4274(98)00186-6

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M3 - 学術論文

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AN - SCOPUS:18544406678

SN - 0378-4274

VL - 100-101

SP - 203

EP - 207

JO - Toxicology Letters

JF - Toxicology Letters

ER -

GABAergic mechanisms in the action of general anesthetics

Abstract

Keywords

ASJC Scopus subject areas

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