Abstract
The first thiazolidinedione derivative drug for diabetes, troglitazone, was found to cause fatal hepatotoxicity, although it was judged as safe during the clinical trial. Subsequently, pioglitazone has been clinically used both in Japan and U.S. and has had no fatal cases but caused heart failure. Therefore, careful follow up observation is necessary in these drugs by checking liver function tests and cardiac function.
| Original language | English |
|---|---|
| Pages (from-to) | 2228-2232 |
| Number of pages | 5 |
| Journal | Nihon rinsho. Japanese journal of clinical medicine |
| Volume | 59 |
| Issue number | 11 |
| State | Published - 2001/11 |
ASJC Scopus subject areas
- General Medicine
