Effects of propofol on synaptic transmissions in hippocampal CA1 of the rat

M. Wakasugi; K. Hirota; J. Fujimura; Y. Ito

Effects of propofol on synaptic transmissions in hippocampal CA1 of the rat

M. Wakasugi^*, K. Hirota, J. Fujimura, Y. Ito

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

Abstract

To reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of propofol on synaptic transmission of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. The paired-pulse experiments demonstrated (A) that propofol (10^- ⁵ to 3x10^-3 mol/1) decreased 2nd. PS amplitudes induced by double-pulse stimulation in a dose-dependent manner (ED₅₀ was 7.1x10^-5 mol/1), (B) that propofol (10^-4 mol/1) reduced the paired-pulse facilitation. The effects were blocked by GABA(A) receptor antagonist, bicuculine (10^-4 mol/1). We concluded that the inhibitory effects of propofol on PS were related to the GABAergic pathway.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Hokuriku Journal of Anesthesiology
Volume	30
Issue number	1
State	Published - 1996

Keywords

1-5 protocol
GABA
hippocampus
synaptic transmissions

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Cite this

@article{87d99f0c435c47c5a6551114e5f4acb9,

title = "Effects of propofol on synaptic transmissions in hippocampal CA1 of the rat",

abstract = "To reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of propofol on synaptic transmission of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. The paired-pulse experiments demonstrated (A) that propofol (10- 5 to 3x10-3 mol/1) decreased 2nd. PS amplitudes induced by double-pulse stimulation in a dose-dependent manner (ED50 was 7.1x10-5 mol/1), (B) that propofol (10-4 mol/1) reduced the paired-pulse facilitation. The effects were blocked by GABA(A) receptor antagonist, bicuculine (10-4 mol/1). We concluded that the inhibitory effects of propofol on PS were related to the GABAergic pathway.",

keywords = "1-5 protocol, GABA, hippocampus, synaptic transmissions",

author = "M. Wakasugi and K. Hirota and J. Fujimura and Y. Ito",

year = "1996",

language = "英語",

volume = "30",

pages = "1--5",

journal = "Hokuriku Journal of Anesthesiology",

issn = "0367-5947",

publisher = "Nippon Masui Gakkai Hokuriku Chihokai",

number = "1",

}

TY - JOUR

T1 - Effects of propofol on synaptic transmissions in hippocampal CA1 of the rat

AU - Wakasugi, M.

AU - Hirota, K.

AU - Fujimura, J.

AU - Ito, Y.

PY - 1996

Y1 - 1996

N2 - To reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of propofol on synaptic transmission of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. The paired-pulse experiments demonstrated (A) that propofol (10- 5 to 3x10-3 mol/1) decreased 2nd. PS amplitudes induced by double-pulse stimulation in a dose-dependent manner (ED50 was 7.1x10-5 mol/1), (B) that propofol (10-4 mol/1) reduced the paired-pulse facilitation. The effects were blocked by GABA(A) receptor antagonist, bicuculine (10-4 mol/1). We concluded that the inhibitory effects of propofol on PS were related to the GABAergic pathway.

AB - To reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of propofol on synaptic transmission of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. The paired-pulse experiments demonstrated (A) that propofol (10- 5 to 3x10-3 mol/1) decreased 2nd. PS amplitudes induced by double-pulse stimulation in a dose-dependent manner (ED50 was 7.1x10-5 mol/1), (B) that propofol (10-4 mol/1) reduced the paired-pulse facilitation. The effects were blocked by GABA(A) receptor antagonist, bicuculine (10-4 mol/1). We concluded that the inhibitory effects of propofol on PS were related to the GABAergic pathway.

KW - 1-5 protocol

KW - GABA

KW - hippocampus

KW - synaptic transmissions

UR - http://www.scopus.com/inward/record.url?scp=0029798661&partnerID=8YFLogxK

M3 - 学術論文

AN - SCOPUS:0029798661

SN - 0367-5947

VL - 30

SP - 1

EP - 5

JO - Hokuriku Journal of Anesthesiology

JF - Hokuriku Journal of Anesthesiology

IS - 1

ER -

Effects of propofol on synaptic transmissions in hippocampal CA1 of the rat

Abstract

Keywords

ASJC Scopus subject areas

Fingerprint

Cite this