Effects of ketamine on EPSP and population spike in hippocampal CA1 of the rat

M. Wakasugi; K. Hirota; J. Fujimura; Y. Ito

Effects of ketamine on EPSP and population spike in hippocampal CA1 of the rat

M. Wakasugi^*, K. Hirota, J. Fujimura, Y. Ito

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

Abstract

In order to reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of ketamine on synaptic transmissions of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. Ketamine (10^-5 to 3 x 10^-3 mol/l) decreased both EPSP slopes and PS amplitudes in a dose-dependent manner (ED₅₀s were 8.0 x 10^-4 and 1.1 x 10^-3 mol/l, respectively). The effects were partially blocked by GABA(A) receptor antagonist, bicuculline (10^-4 mol/l). We concluded that the inhibitory effects of ketamine on PSs were due to the reduction of EPSPs, and that the ketamine depression of synaptic transmissions may be at least related to GABA(A) receptor.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Anesthesia and Resuscitation
Volume	32
Issue number	2
State	Published - 1996

Keywords

GABA
hippocampus
ketamine

ASJC Scopus subject areas

Emergency Medicine
Anesthesiology and Pain Medicine

Cite this

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title = "Effects of ketamine on EPSP and population spike in hippocampal CA1 of the rat",

abstract = "In order to reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of ketamine on synaptic transmissions of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. Ketamine (10-5 to 3 x 10-3 mol/l) decreased both EPSP slopes and PS amplitudes in a dose-dependent manner (ED50s were 8.0 x 10-4 and 1.1 x 10-3 mol/l, respectively). The effects were partially blocked by GABA(A) receptor antagonist, bicuculline (10-4 mol/l). We concluded that the inhibitory effects of ketamine on PSs were due to the reduction of EPSPs, and that the ketamine depression of synaptic transmissions may be at least related to GABA(A) receptor.",

keywords = "GABA, hippocampus, ketamine",

author = "M. Wakasugi and K. Hirota and J. Fujimura and Y. Ito",

year = "1996",

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T1 - Effects of ketamine on EPSP and population spike in hippocampal CA1 of the rat

AU - Wakasugi, M.

AU - Hirota, K.

AU - Fujimura, J.

AU - Ito, Y.

PY - 1996

Y1 - 1996

N2 - In order to reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of ketamine on synaptic transmissions of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. Ketamine (10-5 to 3 x 10-3 mol/l) decreased both EPSP slopes and PS amplitudes in a dose-dependent manner (ED50s were 8.0 x 10-4 and 1.1 x 10-3 mol/l, respectively). The effects were partially blocked by GABA(A) receptor antagonist, bicuculline (10-4 mol/l). We concluded that the inhibitory effects of ketamine on PSs were due to the reduction of EPSPs, and that the ketamine depression of synaptic transmissions may be at least related to GABA(A) receptor.

AB - In order to reveal the mechanisms of general anesthesia in the central nervous system, we have examined the effects of ketamine on synaptic transmissions of Shaffer collateral fiber input CA1 pyramidal neurones in hippocampal slices of the rat. Ketamine (10-5 to 3 x 10-3 mol/l) decreased both EPSP slopes and PS amplitudes in a dose-dependent manner (ED50s were 8.0 x 10-4 and 1.1 x 10-3 mol/l, respectively). The effects were partially blocked by GABA(A) receptor antagonist, bicuculline (10-4 mol/l). We concluded that the inhibitory effects of ketamine on PSs were due to the reduction of EPSPs, and that the ketamine depression of synaptic transmissions may be at least related to GABA(A) receptor.

KW - GABA

KW - hippocampus

KW - ketamine

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M3 - 学術論文

AN - SCOPUS:0029750212

SN - 0385-1664

VL - 32

SP - 143

EP - 146

JO - Anesthesia and Resuscitation

JF - Anesthesia and Resuscitation

IS - 2

ER -

Effects of ketamine on EPSP and population spike in hippocampal CA1 of the rat

Abstract

Keywords

ASJC Scopus subject areas

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