TY - JOUR
T1 - Effects of Eppikahangeto, a Kampo formula, and Ephedrae herba against citric acid-induced laryngeal cough in guinea pigs
AU - Minamizawa, Kiyoshi
AU - Goto, Hirozo
AU - Shimada, Yutaka
AU - Terasawa, Katsutoshi
AU - Haji, Akira
PY - 2006
Y1 - 2006
N2 - To evaluate the efficacy of three common antitussive Kampo formulas, eppikahangeto (EPP), bakumondoto (BAK), and shoseiryutogomakyokansekito (SGM), a new cough model of guinea pig was used, which could specifically induce a laryngeal cough by microinjection of citric acid solution into the larynx. Kampo extract was dissolved in water and the animals were given access ad libitum for 3 days, and then the number of coughs during 10 min was counted. EPP extract decreased the number of coughs dose-dependently (0.3% extract, -22.9 ± 6.6%, P<0.01; 1.0% extract, -32.4 ± 5.5%, P<0.01). BAK extract and SGM extract had no significant effect. Intraperitoneal injection of codeine (60 mg/kg) also decreased the number of coughs (-36.1 ± 9.1%, P<0.05). Furthermore, Ephedrae herba (EH) extract reduced the number of coughs (-18.3 ± 6.0%, P<0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH.
AB - To evaluate the efficacy of three common antitussive Kampo formulas, eppikahangeto (EPP), bakumondoto (BAK), and shoseiryutogomakyokansekito (SGM), a new cough model of guinea pig was used, which could specifically induce a laryngeal cough by microinjection of citric acid solution into the larynx. Kampo extract was dissolved in water and the animals were given access ad libitum for 3 days, and then the number of coughs during 10 min was counted. EPP extract decreased the number of coughs dose-dependently (0.3% extract, -22.9 ± 6.6%, P<0.01; 1.0% extract, -32.4 ± 5.5%, P<0.01). BAK extract and SGM extract had no significant effect. Intraperitoneal injection of codeine (60 mg/kg) also decreased the number of coughs (-36.1 ± 9.1%, P<0.05). Furthermore, Ephedrae herba (EH) extract reduced the number of coughs (-18.3 ± 6.0%, P<0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH.
KW - Antitussive effect
KW - Ephedrae herba
KW - Eppikahangeto
KW - Kampo medicine
KW - Laryngeal cough
UR - http://www.scopus.com/inward/record.url?scp=33745324696&partnerID=8YFLogxK
U2 - 10.1254/jphs.FP0060135
DO - 10.1254/jphs.FP0060135
M3 - 学術論文
C2 - 16778362
AN - SCOPUS:33745324696
SN - 1347-8613
VL - 101
SP - 118
EP - 125
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 2
ER -