Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats

Masaru Minami; Shin Ichi Kimura; Toru Endo; Naoya Hamaue; Masahiko Hirafuji; Yoshio Monma; Hiroko Togashi; Mitsuhiro Yoshioka; Hideya Saito; Shiro Watanabe; Tetsuyuki Kobayashi; Harumi Okuyama

doi:10.1016/S0306-3623(96)00487-9

Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats

Masaru Minami^*, Shin Ichi Kimura, Toru Endo, Naoya Hamaue, Masahiko Hirafuji, Yoshio Monma, Hiroko Togashi, Mitsuhiro Yoshioka, Hideya Saito, Shiro Watanabe, Tetsuyuki Kobayashi, Harumi Okuyama

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

1. Dietary docosahexaenoic acid (DHA) suppressed the age dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.

Original language	English
Pages (from-to)	401-407
Number of pages	7
Journal	General Pharmacology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/S0306-3623(96)00487-9
State	Published - 1997/09

Keywords

Ambulatory activity
Circadian rhythm
Docosahexaenoic acid (DHA)
Life span
Stroke-prone spontaneously hypertensive rats (SHRSP)

ASJC Scopus subject areas

Pharmacology

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10.1016/S0306-3623(96)00487-9

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Minami, M., Kimura, S. I., Endo, T., Hamaue, N., Hirafuji, M., Monma, Y., Togashi, H., Yoshioka, M., Saito, H., Watanabe, S., Kobayashi, T., & Okuyama, H. (1997). Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats. General Pharmacology, 29(3), 401-407. https://doi.org/10.1016/S0306-3623(96)00487-9

@article{0cbd54929cca42f2ace3377e50ee70ca,

title = "Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats",

abstract = "1. Dietary docosahexaenoic acid (DHA) suppressed the age dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.",

keywords = "Ambulatory activity, Circadian rhythm, Docosahexaenoic acid (DHA), Life span, Stroke-prone spontaneously hypertensive rats (SHRSP)",

author = "Masaru Minami and Kimura, {Shin Ichi} and Toru Endo and Naoya Hamaue and Masahiko Hirafuji and Yoshio Monma and Hiroko Togashi and Mitsuhiro Yoshioka and Hideya Saito and Shiro Watanabe and Tetsuyuki Kobayashi and Harumi Okuyama",

note = "Funding Information: their technical assistance and for their helpful discussions. SHRSP and normotensive control Wistar-Kyoto rats (WKY) were ori~nally donated by the late Prof. Kozo Okamoto, Department of Pathology, Kinki University School of Medicine, Osaka, Japan. This work was supported in part by grants from the Takeda Science Foundation and the Sasakawa Science Foundation.",

year = "1997",

month = sep,

doi = "10.1016/S0306-3623(96)00487-9",

language = "英語",

volume = "29",

pages = "401--407",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier B.V.",

number = "3",

}

Minami, M, Kimura, SI, Endo, T, Hamaue, N, Hirafuji, M, Monma, Y, Togashi, H, Yoshioka, M, Saito, H, Watanabe, S, Kobayashi, T & Okuyama, H 1997, 'Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats', General Pharmacology, vol. 29, no. 3, pp. 401-407. https://doi.org/10.1016/S0306-3623(96)00487-9

TY - JOUR

T1 - Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats

AU - Minami, Masaru

AU - Kimura, Shin Ichi

AU - Endo, Toru

AU - Hamaue, Naoya

AU - Hirafuji, Masahiko

AU - Monma, Yoshio

AU - Togashi, Hiroko

AU - Yoshioka, Mitsuhiro

AU - Saito, Hideya

AU - Watanabe, Shiro

AU - Kobayashi, Tetsuyuki

AU - Okuyama, Harumi

N1 - Funding Information: their technical assistance and for their helpful discussions. SHRSP and normotensive control Wistar-Kyoto rats (WKY) were ori~nally donated by the late Prof. Kozo Okamoto, Department of Pathology, Kinki University School of Medicine, Osaka, Japan. This work was supported in part by grants from the Takeda Science Foundation and the Sasakawa Science Foundation.

PY - 1997/9

Y1 - 1997/9

N2 - 1. Dietary docosahexaenoic acid (DHA) suppressed the age dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.

AB - 1. Dietary docosahexaenoic acid (DHA) suppressed the age dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.

KW - Ambulatory activity

KW - Circadian rhythm

KW - Docosahexaenoic acid (DHA)

KW - Life span

KW - Stroke-prone spontaneously hypertensive rats (SHRSP)

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U2 - 10.1016/S0306-3623(96)00487-9

DO - 10.1016/S0306-3623(96)00487-9

M3 - 学術論文

AN - SCOPUS:0030821271

SN - 0306-3623

VL - 29

SP - 401

EP - 407

JO - General Pharmacology

JF - General Pharmacology

IS - 3

ER -

Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats

Abstract

Keywords

ASJC Scopus subject areas

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