TY - JOUR
T1 - Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia
T2 - A three-dimensional analysis with sLORETA
AU - Sumiyoshi, Tomiki
AU - Higuchi, Yuko
AU - Itoh, Toru
AU - Matsui, Mie
AU - Arai, Hirofumi
AU - Suzuki, Michio
AU - Kurachi, Masayoshi
AU - Sumiyoshi, Chika
AU - Kawasaki, Yasuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science (No. 16591126 and 19591345), Health and Labor Sciences Research Grants, and Mitsubishi Pharma Research Foundation. These funding bodies had no further role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
PY - 2009/6/30
Y1 - 2009/6/30
N2 - The purpose of this study was to determine if perospirone, a second generation antipsychotic drug and partial agonist at serotonin-5-HT1A receptors, enhances electrophysiological activity, such as event-related potentials (ERPs), in frontal brain regions, as well as cognitive function in subjects with schizophrenia. P300 current source images were obtained by means of standardized low resolution brain electromagnetic tomography (sLORETA) before and after treatment with perospirone for 6 months. Perospirone significantly increased P300 current source density in the left superior frontal gyrus, and improved positive symptoms and performance on the script tasks, a measure of verbal social cognition, while verbal learning memory tended to be improved. There was a significant correlation between the changes in P300 amplitude on the left frontal lead and those in social cognition. These results suggest the changes in three-dimensional distribution of cortical activity, as demonstrated by sLORETA, may mediate some of the actions of antipsychotic drugs. The distinct cognition-enhancing profile of perospirone in patients with schizophrenia may be related to its actions on 5-HT1A receptors.
AB - The purpose of this study was to determine if perospirone, a second generation antipsychotic drug and partial agonist at serotonin-5-HT1A receptors, enhances electrophysiological activity, such as event-related potentials (ERPs), in frontal brain regions, as well as cognitive function in subjects with schizophrenia. P300 current source images were obtained by means of standardized low resolution brain electromagnetic tomography (sLORETA) before and after treatment with perospirone for 6 months. Perospirone significantly increased P300 current source density in the left superior frontal gyrus, and improved positive symptoms and performance on the script tasks, a measure of verbal social cognition, while verbal learning memory tended to be improved. There was a significant correlation between the changes in P300 amplitude on the left frontal lead and those in social cognition. These results suggest the changes in three-dimensional distribution of cortical activity, as demonstrated by sLORETA, may mediate some of the actions of antipsychotic drugs. The distinct cognition-enhancing profile of perospirone in patients with schizophrenia may be related to its actions on 5-HT1A receptors.
KW - 5-HT agonism
KW - Atypical antipsychotic drugs
KW - Cognitive function
KW - Event-related potentials
KW - Second generation
KW - Social cognition
UR - http://www.scopus.com/inward/record.url?scp=67349194712&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2008.07.005
DO - 10.1016/j.pscychresns.2008.07.005
M3 - 学術論文
C2 - 19386475
AN - SCOPUS:67349194712
SN - 0925-4927
VL - 172
SP - 180
EP - 183
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -
