Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis

Yuya Ishida; Sakura Yonoichi; Yukako Hara; Asuka Shoda; Mako Kimura; Midori Murata; Makiko Ito; Sarika Nunobiki; Ayano Yoshimoto; Youhei Mantani; Toshifumi Yokoyama; Tetsushi Hirano; Eiko Matsuo; Yoshinori Ikenaka; Nobuhiko Hoshi

doi:10.1292/jvms.23-0515

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis

Yuya Ishida, Sakura Yonoichi, Yukako Hara, Asuka Shoda, Mako Kimura, Midori Murata, Makiko Ito, Sarika Nunobiki, Ayano Yoshimoto, Youhei Mantani, Toshifumi Yokoyama, Tetsushi Hirano, Eiko Matsuo, Yoshinori Ikenaka, Nobuhiko Hoshi^*

^*Corresponding author for this work

Division of Drug and Structural Research, Life Science Research Center, Organization for Promotion of Research

Research output: Contribution to journal › Comment/debate

Abstract

The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown. We administered a no-adverse-effect-level (NOAEL) dose of CLO to male NC/Nga mice with induced AD and measured, at three time points, key AD symptom indicators: epidermal thickening, mast cell number, total plasma IgE, and histamine levels. CLO increased total plasma IgE levels but reduced epidermal thickening, mast cell number, and plasma histamine levels in the early stages of AD. This demonstrates for the first time that CLO exposure inhibits AD’s early symptoms.

Original language	English
Pages (from-to)	333-339
Number of pages	7
Journal	Journal of Veterinary Medical Science
Volume	86
Issue number	3
DOIs	https://doi.org/10.1292/jvms.23-0515
State	Published - 2024

Keywords

atopic dermatitis
clothianidin
IgE
NC/Nga mice
α7 nAChR

ASJC Scopus subject areas

General Veterinary

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10.1292/jvms.23-0515

Cite this

Ishida, Y., Yonoichi, S., Hara, Y., Shoda, A., Kimura, M., Murata, M., Ito, M., Nunobiki, S., Yoshimoto, A., Mantani, Y., Yokoyama, T., Hirano, T., Matsuo, E., Ikenaka, Y., & Hoshi, N. (2024). Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis. Journal of Veterinary Medical Science, 86(3), 333-339. https://doi.org/10.1292/jvms.23-0515

@article{306b61c220124701afa88418c30c695b,

title = "Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis",

abstract = "The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown. We administered a no-adverse-effect-level (NOAEL) dose of CLO to male NC/Nga mice with induced AD and measured, at three time points, key AD symptom indicators: epidermal thickening, mast cell number, total plasma IgE, and histamine levels. CLO increased total plasma IgE levels but reduced epidermal thickening, mast cell number, and plasma histamine levels in the early stages of AD. This demonstrates for the first time that CLO exposure inhibits AD{\textquoteright}s early symptoms.",

keywords = "atopic dermatitis, clothianidin, IgE, NC/Nga mice, α7 nAChR",

author = "Yuya Ishida and Sakura Yonoichi and Yukako Hara and Asuka Shoda and Mako Kimura and Midori Murata and Makiko Ito and Sarika Nunobiki and Ayano Yoshimoto and Youhei Mantani and Toshifumi Yokoyama and Tetsushi Hirano and Eiko Matsuo and Yoshinori Ikenaka and Nobuhiko Hoshi",

note = "Publisher Copyright: {\textcopyright} 2024 The Japanese Society of Veterinary Science.",

year = "2024",

doi = "10.1292/jvms.23-0515",

language = "英語",

volume = "86",

pages = "333--339",

journal = "Journal of Veterinary Medical Science",

issn = "0916-7250",

publisher = "Japanese Society of Veterinary Science",

number = "3",

}

Ishida, Y, Yonoichi, S, Hara, Y, Shoda, A, Kimura, M, Murata, M, Ito, M, Nunobiki, S, Yoshimoto, A, Mantani, Y, Yokoyama, T, Hirano, T, Matsuo, E, Ikenaka, Y & Hoshi, N 2024, 'Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis', Journal of Veterinary Medical Science, vol. 86, no. 3, pp. 333-339. https://doi.org/10.1292/jvms.23-0515

TY - JOUR

T1 - Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis

AU - Ishida, Yuya

AU - Yonoichi, Sakura

AU - Hara, Yukako

AU - Shoda, Asuka

AU - Kimura, Mako

AU - Murata, Midori

AU - Ito, Makiko

AU - Nunobiki, Sarika

AU - Yoshimoto, Ayano

AU - Mantani, Youhei

AU - Yokoyama, Toshifumi

AU - Hirano, Tetsushi

AU - Matsuo, Eiko

AU - Ikenaka, Yoshinori

AU - Hoshi, Nobuhiko

PY - 2024

Y1 - 2024

N2 - The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown. We administered a no-adverse-effect-level (NOAEL) dose of CLO to male NC/Nga mice with induced AD and measured, at three time points, key AD symptom indicators: epidermal thickening, mast cell number, total plasma IgE, and histamine levels. CLO increased total plasma IgE levels but reduced epidermal thickening, mast cell number, and plasma histamine levels in the early stages of AD. This demonstrates for the first time that CLO exposure inhibits AD’s early symptoms.

AB - The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown. We administered a no-adverse-effect-level (NOAEL) dose of CLO to male NC/Nga mice with induced AD and measured, at three time points, key AD symptom indicators: epidermal thickening, mast cell number, total plasma IgE, and histamine levels. CLO increased total plasma IgE levels but reduced epidermal thickening, mast cell number, and plasma histamine levels in the early stages of AD. This demonstrates for the first time that CLO exposure inhibits AD’s early symptoms.

KW - atopic dermatitis

KW - clothianidin

KW - IgE

KW - NC/Nga mice

KW - α7 nAChR

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U2 - 10.1292/jvms.23-0515

DO - 10.1292/jvms.23-0515

M3 - コメント/討論

C2 - 38311400

AN - SCOPUS:85187912197

SN - 0916-7250

VL - 86

SP - 333

EP - 339

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 3

ER -

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

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