Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

Feng Li; Ken Tanaka; Shiro Watanabe; Yasuhiro Tezuka; Ikuo Saiki

doi:10.1248/cpb.c13-00546

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

Feng Li^*, Ken Tanaka, Shiro Watanabe, Yasuhiro Tezuka, Ikuo Saiki

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2-21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

Original language	English
Pages (from-to)	1318-1322
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	61
Issue number	12
DOIs	https://doi.org/10.1248/cpb.c13-00546
State	Published - 2013/12

Keywords

Dipasperoside A
Dipsacus asper
Nitric oxide production inhibitory activity
Pyridine alkaloid-coupled iridoid glucoside

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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title = "Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper",

abstract = "A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2-21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.",

keywords = "Dipasperoside A, Dipsacus asper, Nitric oxide production inhibitory activity, Pyridine alkaloid-coupled iridoid glucoside",

author = "Feng Li and Ken Tanaka and Shiro Watanabe and Yasuhiro Tezuka and Ikuo Saiki",

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AU - Li, Feng

AU - Tanaka, Ken

AU - Watanabe, Shiro

AU - Tezuka, Yasuhiro

AU - Saiki, Ikuo

PY - 2013/12

Y1 - 2013/12

N2 - A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2-21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

AB - A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2-21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.

KW - Dipasperoside A

KW - Dipsacus asper

KW - Nitric oxide production inhibitory activity

KW - Pyridine alkaloid-coupled iridoid glucoside

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DO - 10.1248/cpb.c13-00546

M3 - 学術論文

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AN - SCOPUS:84890062938

SN - 0009-2363

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Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper

Abstract

Keywords

ASJC Scopus subject areas

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