Daptomycin-induced eosinophilic pneumonia and a review of the published literature

Yoshitsugu Higashi; Shigeki Nakamura; Yasuhiro Tsuji; Chika Ogami; Kaoru Matsumoto; Koyomi Kawago; Kotaro Tokui; Ryuji Hayashi; Ippei Sakamaki; Yoshihiro Yamamoto

doi:10.2169/internalmedicine.9010-17

Daptomycin-induced eosinophilic pneumonia and a review of the published literature

Yoshitsugu Higashi, Shigeki Nakamura, Yasuhiro Tsuji, Chika Ogami, Kaoru Matsumoto, Koyomi Kawago, Kotaro Tokui, Ryuji Hayashi, Ippei Sakamaki, Yoshihiro Yamamoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (C_min) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

Original language	English
Pages (from-to)	253-258
Number of pages	6
Journal	Internal Medicine
Volume	57
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.9010-17
State	Published - 2018

Keywords

Daptomycin
Eosinophilic pneumonia
Therapeutic drug monitoring

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.9010-17

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title = "Daptomycin-induced eosinophilic pneumonia and a review of the published literature",

abstract = "A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.",

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AU - Higashi, Yoshitsugu

AU - Nakamura, Shigeki

AU - Tsuji, Yasuhiro

AU - Ogami, Chika

AU - Matsumoto, Kaoru

AU - Kawago, Koyomi

AU - Tokui, Kotaro

AU - Hayashi, Ryuji

AU - Sakamaki, Ippei

AU - Yamamoto, Yoshihiro

PY - 2018

Y1 - 2018

N2 - A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

AB - A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy. The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

KW - Daptomycin

KW - Eosinophilic pneumonia

KW - Therapeutic drug monitoring

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Daptomycin-induced eosinophilic pneumonia and a review of the published literature

Abstract

Keywords

ASJC Scopus subject areas

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