TY - JOUR
T1 - Cytotoxic potential of dihydrochalcones from Eriosema glomeratum and their semi-synthetic derivatives
AU - Tabakam, Gaétan Tchangou
AU - Kodama, Takeshi
AU - Tchuenmogne, Marthe Aimée Tchuente
AU - Hoang, Nhat Nam
AU - Nomin-Erdene, Battsengel
AU - Ngouela, Silvère Augustin
AU - Tene, Mathieu
AU - Morita, Hiroyuki
AU - Awouafack, Maurice Ducret
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024
Y1 - 2024
N2 - In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (1-7) from Eriosema glomeratum and the preparation of eight derivatives (8-15). The cytotoxicity of samples was evaluated against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cells. The CH2Cl2/MeOH extract of the aerial part had strong cytotoxicity against all cells [IC50 11.2 (MCF-7), 8.4 (HeLa) and 13.1 (A549) μg/mL]. A strong activity was also displayed by the n-hexane fraction on MCF-7 (IC50 11.2 μg/mL). The precursor 3 and the derivative 8 were specifically found as strong cytotoxic agents toward MCF-7 (7.6 μM) and HeLa (3.1 μM), respectively and were more effective than the positive control. Derivatives 8 (3.1 μM) and 9 (21.3 μM) against HeLa were most potent than their precursor 3 (23.7 μM). This is the first preparation of 8-14 as well as the cytotoxicity of 3, 4, 8-15, fractions, and extract.
AB - In the search of cytotoxic dihydrochalcones, this investigation led to the isolation of seven compounds (1-7) from Eriosema glomeratum and the preparation of eight derivatives (8-15). The cytotoxicity of samples was evaluated against lung (A549), breast (MCF-7), and cervical (HeLa) human cancer cells. The CH2Cl2/MeOH extract of the aerial part had strong cytotoxicity against all cells [IC50 11.2 (MCF-7), 8.4 (HeLa) and 13.1 (A549) μg/mL]. A strong activity was also displayed by the n-hexane fraction on MCF-7 (IC50 11.2 μg/mL). The precursor 3 and the derivative 8 were specifically found as strong cytotoxic agents toward MCF-7 (7.6 μM) and HeLa (3.1 μM), respectively and were more effective than the positive control. Derivatives 8 (3.1 μM) and 9 (21.3 μM) against HeLa were most potent than their precursor 3 (23.7 μM). This is the first preparation of 8-14 as well as the cytotoxicity of 3, 4, 8-15, fractions, and extract.
KW - Cytotoxicity
KW - Eriosema glomeratum
KW - erioschalcones A and B
KW - semi-synthesis
UR - http://www.scopus.com/inward/record.url?scp=85136038121&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2111563
DO - 10.1080/14786419.2022.2111563
M3 - 学術論文
C2 - 35968769
AN - SCOPUS:85136038121
SN - 1478-6419
VL - 38
SP - 186
EP - 197
JO - Natural Product Research
JF - Natural Product Research
IS - 2
ER -
