Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group

Munehisa Kito; Keisuke Ae; Masanori Okamoto; Makoto Endo; Kunihiro Ikuta; Akihiko Takeuchi; Naohiro Yasuda; Taketoshi Yasuda; Yoshinori Imura; Takeshi Morii; Kazutaka Kikuta; Teruya Kawamoto; Yutaka Nezu; Ichiro Baba; Shusa Ohshika; Takeshi Uehara; Takafumi Ueda; Jun Takahashi; Hirotaka Kawano

doi:10.3390/cancers15082314

Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group

Munehisa Kito, Keisuke Ae, Masanori Okamoto^*, Makoto Endo, Kunihiro Ikuta, Akihiko Takeuchi, Naohiro Yasuda, Taketoshi Yasuda, Yoshinori Imura, Takeshi Morii, Kazutaka Kikuta, Teruya Kawamoto, Yutaka Nezu, Ichiro Baba, Shusa Ohshika, Takeshi Uehara, Takafumi Ueda, Jun Takahashi, Hirotaka Kawano

^*Corresponding author for this work

Orthopaedic Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 and 2019 in the Japanese sarcoma network. Twenty-two cases were surgically treated and two cases were treated with radical radiotherapy (RT). The pathological margin was R0 in 14 cases, R1 in 7 cases, and R2 in 1 case. The best overall response in the two patients who underwent radical RT was one complete response and one partial response. Local relapse occurred in 20.8% of patients. Local relapse-free survival (LRFS) was 91.3% at 2 years and 75.4% at 5 years. In univariate analysis, tumors of 5 cm or more were significantly more likely to cause local relapse (p < 0.01). In terms of the treatment of relapsed tumors, surgery was performed in two cases and radical RT was performed in three cases. None of the patients experienced a second local relapse. Disease-specific survival was 100% at 5 years. A wide excision aimed at the microscopically R0 margin is considered the standard treatment for LGMS. However, RT may be a viable option in unresectable cases or in cases where surgery is expected to cause significant functional impairment.

Original language	English
Article number	2314
Journal	Cancers
Volume	15
Issue number	8
DOIs	https://doi.org/10.3390/cancers15082314
State	Published - 2023/04

Keywords

local relapse
low-grade myofibroblastic sarcoma
prognosis
radiotherapy
rare sarcoma
wide excision

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers15082314

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Kito, M., Ae, K., Okamoto, M., Endo, M., Ikuta, K., Takeuchi, A., Yasuda, N., Yasuda, T., Imura, Y., Morii, T., Kikuta, K., Kawamoto, T., Nezu, Y., Baba, I., Ohshika, S., Uehara, T., Ueda, T., Takahashi, J., & Kawano, H. (2023). Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group. Cancers, 15(8), Article 2314. https://doi.org/10.3390/cancers15082314

@article{e8d20bf62fb74893aae5d52282b8e524,

title = "Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group",

abstract = "This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 and 2019 in the Japanese sarcoma network. Twenty-two cases were surgically treated and two cases were treated with radical radiotherapy (RT). The pathological margin was R0 in 14 cases, R1 in 7 cases, and R2 in 1 case. The best overall response in the two patients who underwent radical RT was one complete response and one partial response. Local relapse occurred in 20.8% of patients. Local relapse-free survival (LRFS) was 91.3% at 2 years and 75.4% at 5 years. In univariate analysis, tumors of 5 cm or more were significantly more likely to cause local relapse (p < 0.01). In terms of the treatment of relapsed tumors, surgery was performed in two cases and radical RT was performed in three cases. None of the patients experienced a second local relapse. Disease-specific survival was 100% at 5 years. A wide excision aimed at the microscopically R0 margin is considered the standard treatment for LGMS. However, RT may be a viable option in unresectable cases or in cases where surgery is expected to cause significant functional impairment.",

keywords = "local relapse, low-grade myofibroblastic sarcoma, prognosis, radiotherapy, rare sarcoma, wide excision",

author = "Munehisa Kito and Keisuke Ae and Masanori Okamoto and Makoto Endo and Kunihiro Ikuta and Akihiko Takeuchi and Naohiro Yasuda and Taketoshi Yasuda and Yoshinori Imura and Takeshi Morii and Kazutaka Kikuta and Teruya Kawamoto and Yutaka Nezu and Ichiro Baba and Shusa Ohshika and Takeshi Uehara and Takafumi Ueda and Jun Takahashi and Hirotaka Kawano",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = apr,

doi = "10.3390/cancers15082314",

language = "英語",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

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Kito, M, Ae, K, Okamoto, M, Endo, M, Ikuta, K, Takeuchi, A, Yasuda, N, Yasuda, T, Imura, Y, Morii, T, Kikuta, K, Kawamoto, T, Nezu, Y, Baba, I, Ohshika, S, Uehara, T, Ueda, T, Takahashi, J & Kawano, H 2023, 'Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group', Cancers, vol. 15, no. 8, 2314. https://doi.org/10.3390/cancers15082314

TY - JOUR

T1 - Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan

T2 - A Multicenter Study from the Japanese Musculoskeletal Oncology Group

AU - Kito, Munehisa

AU - Ae, Keisuke

AU - Okamoto, Masanori

AU - Endo, Makoto

AU - Ikuta, Kunihiro

AU - Takeuchi, Akihiko

AU - Yasuda, Naohiro

AU - Yasuda, Taketoshi

AU - Imura, Yoshinori

AU - Morii, Takeshi

AU - Kikuta, Kazutaka

AU - Kawamoto, Teruya

AU - Nezu, Yutaka

AU - Baba, Ichiro

AU - Ohshika, Shusa

AU - Uehara, Takeshi

AU - Ueda, Takafumi

AU - Takahashi, Jun

AU - Kawano, Hirotaka

PY - 2023/4

Y1 - 2023/4

N2 - This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 and 2019 in the Japanese sarcoma network. Twenty-two cases were surgically treated and two cases were treated with radical radiotherapy (RT). The pathological margin was R0 in 14 cases, R1 in 7 cases, and R2 in 1 case. The best overall response in the two patients who underwent radical RT was one complete response and one partial response. Local relapse occurred in 20.8% of patients. Local relapse-free survival (LRFS) was 91.3% at 2 years and 75.4% at 5 years. In univariate analysis, tumors of 5 cm or more were significantly more likely to cause local relapse (p < 0.01). In terms of the treatment of relapsed tumors, surgery was performed in two cases and radical RT was performed in three cases. None of the patients experienced a second local relapse. Disease-specific survival was 100% at 5 years. A wide excision aimed at the microscopically R0 margin is considered the standard treatment for LGMS. However, RT may be a viable option in unresectable cases or in cases where surgery is expected to cause significant functional impairment.

AB - This retrospective multicenter study aimed to analyze the clinical features and prognosis of 24 patients diagnosed with LGMS between 2002 and 2019 in the Japanese sarcoma network. Twenty-two cases were surgically treated and two cases were treated with radical radiotherapy (RT). The pathological margin was R0 in 14 cases, R1 in 7 cases, and R2 in 1 case. The best overall response in the two patients who underwent radical RT was one complete response and one partial response. Local relapse occurred in 20.8% of patients. Local relapse-free survival (LRFS) was 91.3% at 2 years and 75.4% at 5 years. In univariate analysis, tumors of 5 cm or more were significantly more likely to cause local relapse (p < 0.01). In terms of the treatment of relapsed tumors, surgery was performed in two cases and radical RT was performed in three cases. None of the patients experienced a second local relapse. Disease-specific survival was 100% at 5 years. A wide excision aimed at the microscopically R0 margin is considered the standard treatment for LGMS. However, RT may be a viable option in unresectable cases or in cases where surgery is expected to cause significant functional impairment.

KW - local relapse

KW - low-grade myofibroblastic sarcoma

KW - prognosis

KW - radiotherapy

KW - rare sarcoma

KW - wide excision

UR - http://www.scopus.com/inward/record.url?scp=85153852164&partnerID=8YFLogxK

U2 - 10.3390/cancers15082314

DO - 10.3390/cancers15082314

M3 - 学術論文

C2 - 37190242

AN - SCOPUS:85153852164

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 8

M1 - 2314

ER -

Clinical Outcome of Low-Grade Myofibroblastic Sarcoma in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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