Behçet's disease with severe autonomic disorders developing after herpes zoster

Serina Koto; Masataka Umeda; Hiroaki Kawano; Yushiro Endo; Toshimasa Shimizu; Tomohiro Koga; Kunihiro Ichinose; Hideki Nakamura; Akihiro Mukaino; Osamu Higuchi; Shunya Nakane; Atsushi Kawakami

doi:10.2169/internalmedicine.3954-19

Behçet's disease with severe autonomic disorders developing after herpes zoster

Serina Koto, Masataka Umeda^*, Hiroaki Kawano, Yushiro Endo, Toshimasa Shimizu, Tomohiro Koga, Kunihiro Ichinose, Hideki Nakamura, Akihiro Mukaino, Osamu Higuchi, Shunya Nakane, Atsushi Kawakami

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

Original language	English
Pages (from-to)	1099-1104
Number of pages	6
Journal	Internal Medicine
Volume	59
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.3954-19
State	Published - 2020

Keywords

Autonomic disorder
Behçet's disease
Herpes zoster
IL-10

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.3954-19

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@article{376ab7eb83a6401a92ad11f17874720c,

title = "Beh{\c c}et's disease with severe autonomic disorders developing after herpes zoster",

abstract = "A 58-year-old Japanese woman with herpes zoster developed Beh{\c c}et's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.",

keywords = "Autonomic disorder, Beh{\c c}et's disease, Herpes zoster, IL-10",

author = "Serina Koto and Masataka Umeda and Hiroaki Kawano and Yushiro Endo and Toshimasa Shimizu and Tomohiro Koga and Kunihiro Ichinose and Hideki Nakamura and Akihiro Mukaino and Osamu Higuchi and Shunya Nakane and Atsushi Kawakami",

year = "2020",

doi = "10.2169/internalmedicine.3954-19",

language = "英語",

volume = "59",

pages = "1099--1104",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "8",

}

TY - JOUR

T1 - Behçet's disease with severe autonomic disorders developing after herpes zoster

AU - Koto, Serina

AU - Umeda, Masataka

AU - Kawano, Hiroaki

AU - Endo, Yushiro

AU - Shimizu, Toshimasa

AU - Koga, Tomohiro

AU - Ichinose, Kunihiro

AU - Nakamura, Hideki

AU - Mukaino, Akihiro

AU - Higuchi, Osamu

AU - Nakane, Shunya

AU - Kawakami, Atsushi

PY - 2020

Y1 - 2020

N2 - A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

AB - A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-blocker successfully controlled both the disease activity of BD and the autonomic disorders. A cytokine multiplex analysis of her serum revealed the elevation of proinflammatory cytokines [interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor alfa (TNFα), and interferon gamma (IFN-γ)] and a low IL-10 concentration. IL-10 production is reported to be important for defense against herpes zoster virus (VZV). Insufficient IL-10 production is reported in BD. The reactivation of VZV with this cytokine profile suggests that BD will develop with various symptoms, including severe autonomic disorders.

KW - Autonomic disorder

KW - Behçet's disease

KW - Herpes zoster

KW - IL-10

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U2 - 10.2169/internalmedicine.3954-19

DO - 10.2169/internalmedicine.3954-19

M3 - 学術論文

C2 - 32009095

AN - SCOPUS:85083544211

SN - 0918-2918

VL - 59

SP - 1099

EP - 1104

JO - Internal Medicine

JF - Internal Medicine

IS - 8

ER -

Behçet's disease with severe autonomic disorders developing after herpes zoster

Abstract

Keywords

ASJC Scopus subject areas

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