Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy

Masashi Morita; Ikuko Takahashi; Mariko Kanai; Fumito Okafuji; Makoto Iwashima; Toshimitsu Hayashi; Shiro Watanabe; Tomohito Hamazaki; Nobuyuki Shimozawa; Yasuyuki Suzuki; Hirokazu Furuya; Takeshi Yamada; Tsuneo Imanaka

doi:10.1016/j.febslet.2004.11.102

Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy

Masashi Morita, Ikuko Takahashi, Mariko Kanai, Fumito Okafuji, Makoto Iwashima, Toshimitsu Hayashi, Shiro Watanabe, Tomohito Hamazaki, Nobuyuki Shimozawa, Yasuyuki Suzuki, Hirokazu Furuya, Takeshi Yamada, Tsuneo Imanaka

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA β-oxidation activity. Furthermore, the incorporation of [1- ¹⁴C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.

Original language	English
Pages (from-to)	409-414
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2004.11.102
State	Published - 2005/01/17

Keywords

ATP-binding cassette protein
Adrenoleukodystrophy
Baicalein
Flavonoid
Peroxisome
Very long chain fatty acid

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2004.11.102

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Morita, M., Takahashi, I., Kanai, M., Okafuji, F., Iwashima, M., Hayashi, T., Watanabe, S., Hamazaki, T., Shimozawa, N., Suzuki, Y., Furuya, H., Yamada, T., & Imanaka, T. (2005). Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy. FEBS Letters, 579(2), 409-414. https://doi.org/10.1016/j.febslet.2004.11.102

@article{299a828e8f4646f1829ec122a57b9cba,

title = "Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy",

abstract = "The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA β-oxidation activity. Furthermore, the incorporation of [1- 14C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.",

keywords = "ATP-binding cassette protein, Adrenoleukodystrophy, Baicalein, Flavonoid, Peroxisome, Very long chain fatty acid",

author = "Masashi Morita and Ikuko Takahashi and Mariko Kanai and Fumito Okafuji and Makoto Iwashima and Toshimitsu Hayashi and Shiro Watanabe and Tomohito Hamazaki and Nobuyuki Shimozawa and Yasuyuki Suzuki and Hirokazu Furuya and Takeshi Yamada and Tsuneo Imanaka",

note = "Funding Information: This study was supported by a grant from the Ministry of Health, Labor and Welfare of Japan Society for the Promotion of Science. We appreciate the review of the manuscript prior to submission by Pacific Edit.",

year = "2005",

month = jan,

day = "17",

doi = "10.1016/j.febslet.2004.11.102",

language = "英語",

volume = "579",

pages = "409--414",

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issn = "0014-5793",

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Morita, M, Takahashi, I, Kanai, M, Okafuji, F, Iwashima, M, Hayashi, T, Watanabe, S, Hamazaki, T, Shimozawa, N, Suzuki, Y, Furuya, H, Yamada, T & Imanaka, T 2005, 'Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy', FEBS Letters, vol. 579, no. 2, pp. 409-414. https://doi.org/10.1016/j.febslet.2004.11.102

TY - JOUR

T1 - Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy

AU - Morita, Masashi

AU - Takahashi, Ikuko

AU - Kanai, Mariko

AU - Okafuji, Fumito

AU - Iwashima, Makoto

AU - Hayashi, Toshimitsu

AU - Watanabe, Shiro

AU - Hamazaki, Tomohito

AU - Shimozawa, Nobuyuki

AU - Suzuki, Yasuyuki

AU - Furuya, Hirokazu

AU - Yamada, Takeshi

AU - Imanaka, Tsuneo

N1 - Funding Information: This study was supported by a grant from the Ministry of Health, Labor and Welfare of Japan Society for the Promotion of Science. We appreciate the review of the manuscript prior to submission by Pacific Edit.

PY - 2005/1/17

Y1 - 2005/1/17

N2 - The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA β-oxidation activity. Furthermore, the incorporation of [1- 14C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.

AB - The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA β-oxidation activity. Furthermore, the incorporation of [1- 14C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.

KW - ATP-binding cassette protein

KW - Adrenoleukodystrophy

KW - Baicalein

KW - Flavonoid

KW - Peroxisome

KW - Very long chain fatty acid

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U2 - 10.1016/j.febslet.2004.11.102

DO - 10.1016/j.febslet.2004.11.102

M3 - 学術論文

C2 - 15642351

AN - SCOPUS:19944428428

SN - 0014-5793

VL - 579

SP - 409

EP - 414

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy

Abstract

Keywords

ASJC Scopus subject areas

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