Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis

Makoto Yamakawa; Akihiro Mukaino; Akio Kimura; Yuki Nagasako; Yuki Kitazaki; Yasushi Maeda; Osamu Higuchi; Koutaro Takamatsu; Mari Watari; Nobuaki Yoshikura; Masamichi Ikawa; Izumi Sugimoto; Yasuhisa Sakurai; Hidenori Matsuo; Yukio Ando; Takayoshi Shimohata; Shunya Nakane

doi:10.1016/j.jneuroim.2020.577399

Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis

Makoto Yamakawa, Akihiro Mukaino, Akio Kimura, Yuki Nagasako, Yuki Kitazaki, Yasushi Maeda, Osamu Higuchi, Koutaro Takamatsu, Mari Watari, Nobuaki Yoshikura, Masamichi Ikawa, Izumi Sugimoto, Yasuhisa Sakurai, Hidenori Matsuo, Yukio Ando, Takayoshi Shimohata, Shunya Nakane^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Since autonomic dysfunction is closely associated with autoimmune encephalitis (AE), the objective of this study was to determine the autonomic symptoms and the prevalence of anti-α3 subunit of the ganglionic-type nicotinic acetylcholine receptor (gAChRα3) antibodies in the patients with AE. We reviewed the clinical features of 19 AE patients, and specifically analyzed sera for anti-gAChRα3 antibodies using the luciferase immunoprecipitation system (LIPS) assay. Cardiovascular autonomic symptoms were found to be common in patients with AE, and hypersalivation was seen only in patients with NMDAR encephalitis. LIPS detected anti-gAChRα3 antibodies in the sera from patients with AE (5/29, 26%). This study is the first to demonstrate that clinical characteristics including autonomic symptoms of AE patients with seropositivity for gAChR autoantibodies. It will be important to verify the role of gAChR antibodies in autonomic dysfunction and brain symptoms to clarify the pathogenesis of AE.

Original language	English
Article number	577399
Journal	Journal of Neuroimmunology
Volume	349
DOIs	https://doi.org/10.1016/j.jneuroim.2020.577399
State	Published - 2020/12/15

Keywords

Autoantibody
Autoimmune encephalitis
Autonomic dysfunction
Ganglionic acetylcholine receptor
NMDAR encephalitis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2020.577399

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Yamakawa, M., Mukaino, A., Kimura, A., Nagasako, Y., Kitazaki, Y., Maeda, Y., Higuchi, O., Takamatsu, K., Watari, M., Yoshikura, N., Ikawa, M., Sugimoto, I., Sakurai, Y., Matsuo, H., Ando, Y., Shimohata, T., & Nakane, S. (2020). Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis. Journal of Neuroimmunology, 349, Article 577399. https://doi.org/10.1016/j.jneuroim.2020.577399

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title = "Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis",

abstract = "Since autonomic dysfunction is closely associated with autoimmune encephalitis (AE), the objective of this study was to determine the autonomic symptoms and the prevalence of anti-α3 subunit of the ganglionic-type nicotinic acetylcholine receptor (gAChRα3) antibodies in the patients with AE. We reviewed the clinical features of 19 AE patients, and specifically analyzed sera for anti-gAChRα3 antibodies using the luciferase immunoprecipitation system (LIPS) assay. Cardiovascular autonomic symptoms were found to be common in patients with AE, and hypersalivation was seen only in patients with NMDAR encephalitis. LIPS detected anti-gAChRα3 antibodies in the sera from patients with AE (5/29, 26%). This study is the first to demonstrate that clinical characteristics including autonomic symptoms of AE patients with seropositivity for gAChR autoantibodies. It will be important to verify the role of gAChR antibodies in autonomic dysfunction and brain symptoms to clarify the pathogenesis of AE.",

keywords = "Autoantibody, Autoimmune encephalitis, Autonomic dysfunction, Ganglionic acetylcholine receptor, NMDAR encephalitis",

author = "Makoto Yamakawa and Akihiro Mukaino and Akio Kimura and Yuki Nagasako and Yuki Kitazaki and Yasushi Maeda and Osamu Higuchi and Koutaro Takamatsu and Mari Watari and Nobuaki Yoshikura and Masamichi Ikawa and Izumi Sugimoto and Yasuhisa Sakurai and Hidenori Matsuo and Yukio Ando and Takayoshi Shimohata and Shunya Nakane",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2020.577399",

language = "英語",

volume = "349",

journal = "Journal of Neuroimmunology",

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Yamakawa, M, Mukaino, A, Kimura, A, Nagasako, Y, Kitazaki, Y, Maeda, Y, Higuchi, O, Takamatsu, K, Watari, M, Yoshikura, N, Ikawa, M, Sugimoto, I, Sakurai, Y, Matsuo, H, Ando, Y, Shimohata, T & Nakane, S 2020, 'Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis', Journal of Neuroimmunology, vol. 349, 577399. https://doi.org/10.1016/j.jneuroim.2020.577399

TY - JOUR

T1 - Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis

AU - Yamakawa, Makoto

AU - Mukaino, Akihiro

AU - Kimura, Akio

AU - Nagasako, Yuki

AU - Kitazaki, Yuki

AU - Maeda, Yasushi

AU - Higuchi, Osamu

AU - Takamatsu, Koutaro

AU - Watari, Mari

AU - Yoshikura, Nobuaki

AU - Ikawa, Masamichi

AU - Sugimoto, Izumi

AU - Sakurai, Yasuhisa

AU - Matsuo, Hidenori

AU - Ando, Yukio

AU - Shimohata, Takayoshi

AU - Nakane, Shunya

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Since autonomic dysfunction is closely associated with autoimmune encephalitis (AE), the objective of this study was to determine the autonomic symptoms and the prevalence of anti-α3 subunit of the ganglionic-type nicotinic acetylcholine receptor (gAChRα3) antibodies in the patients with AE. We reviewed the clinical features of 19 AE patients, and specifically analyzed sera for anti-gAChRα3 antibodies using the luciferase immunoprecipitation system (LIPS) assay. Cardiovascular autonomic symptoms were found to be common in patients with AE, and hypersalivation was seen only in patients with NMDAR encephalitis. LIPS detected anti-gAChRα3 antibodies in the sera from patients with AE (5/29, 26%). This study is the first to demonstrate that clinical characteristics including autonomic symptoms of AE patients with seropositivity for gAChR autoantibodies. It will be important to verify the role of gAChR antibodies in autonomic dysfunction and brain symptoms to clarify the pathogenesis of AE.

AB - Since autonomic dysfunction is closely associated with autoimmune encephalitis (AE), the objective of this study was to determine the autonomic symptoms and the prevalence of anti-α3 subunit of the ganglionic-type nicotinic acetylcholine receptor (gAChRα3) antibodies in the patients with AE. We reviewed the clinical features of 19 AE patients, and specifically analyzed sera for anti-gAChRα3 antibodies using the luciferase immunoprecipitation system (LIPS) assay. Cardiovascular autonomic symptoms were found to be common in patients with AE, and hypersalivation was seen only in patients with NMDAR encephalitis. LIPS detected anti-gAChRα3 antibodies in the sera from patients with AE (5/29, 26%). This study is the first to demonstrate that clinical characteristics including autonomic symptoms of AE patients with seropositivity for gAChR autoantibodies. It will be important to verify the role of gAChR antibodies in autonomic dysfunction and brain symptoms to clarify the pathogenesis of AE.

KW - Autoantibody

KW - Autoimmune encephalitis

KW - Autonomic dysfunction

KW - Ganglionic acetylcholine receptor

KW - NMDAR encephalitis

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U2 - 10.1016/j.jneuroim.2020.577399

DO - 10.1016/j.jneuroim.2020.577399

M3 - 学術論文

C2 - 32980672

AN - SCOPUS:85091583782

SN - 0165-5728

VL - 349

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577399

ER -

Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis

Abstract

Keywords

ASJC Scopus subject areas

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