Acid promoted metal free synthesis of triazole-fused heterocycles via intramolecular [3+2] cycloaddition

Youlai Zhang, Mengdi Wang, Junru Li, Qingtong Di, Ziye Tian, Baoquan Chen, Huan Zhang*, Hiroki Tanimoto, Tsumoru Morimoto, Kiyomi Kakiuchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A practical and efficient protocol for the synthesis of triazole-fused heterocycles through intramolecular metal free [3+2] azide-alkyne cycloaddition reaction is described. Range of acids was selected to demonstrate the reaction conditions. Organic azides and propargyl cations generated by acids gave fused triazoles including multivariate rings and heterocycles. Various fused triazoles and bistriazoles were obtained in good yields under mild reaction conditions.

Original languageEnglish
Pages (from-to)943-953
Number of pages11
JournalHeterocycles
Volume96
Issue number5
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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