TY - JOUR
T1 - Abdominal aortic calcification volume as a preoperative prognostic predictor for pancreatic cancer
AU - Yamada, Yuta
AU - Furukawa, Kenei
AU - Haruki, Koichiro
AU - Okui, Norimitsu
AU - Shirai, Yoshihiro
AU - Tsunematsu, Masashi
AU - Yanagaki, Mitsuru
AU - Yasuda, Jungo
AU - Onda, Shinji
AU - Ikegami, Toru
N1 - Publisher Copyright:
© The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. 2024.
PY - 2024
Y1 - 2024
N2 - Purpose: Atherosclerosis and cancer may progress through common pathological factors. This study was performed to investigate the association between the abdominal aortic calcification (AAC) volume and outcomes following surgical treatment for pancreatic cancer. Methods: The subjects of this retrospective study were 194 patients who underwent pancreatic cancer surgery between 2007 and 2020. The AAC volume was assessed through routine preoperative computed tomography. Univariate and multivariate analyses were performed to evaluate the impact of the AAC volume on oncological outcomes. Results: A higher AAC volume (≥ 312 mm3) was identified in 66 (34%) patients, who were significantly older and had a higher prevalence of diabetes and sarcopenia. Univariate analysis revealed several risk factors for overall survival (OS), including male sex, an AAC volume ≥ 312 mm3, elevated carbohydrate antigen 19–9, prolonged operation time, increased intraoperative bleeding, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy. Multivariate analysis identified an AAC volume ≥ 312 mm3, prolonged operation time, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy as independent OS risk factors. The OS rate was significantly lower in the high AAC group than in the low AAC group. Conclusion: The AAC volume may serve as a preoperative prognostic indicator for patients with pancreatic cancer.
AB - Purpose: Atherosclerosis and cancer may progress through common pathological factors. This study was performed to investigate the association between the abdominal aortic calcification (AAC) volume and outcomes following surgical treatment for pancreatic cancer. Methods: The subjects of this retrospective study were 194 patients who underwent pancreatic cancer surgery between 2007 and 2020. The AAC volume was assessed through routine preoperative computed tomography. Univariate and multivariate analyses were performed to evaluate the impact of the AAC volume on oncological outcomes. Results: A higher AAC volume (≥ 312 mm3) was identified in 66 (34%) patients, who were significantly older and had a higher prevalence of diabetes and sarcopenia. Univariate analysis revealed several risk factors for overall survival (OS), including male sex, an AAC volume ≥ 312 mm3, elevated carbohydrate antigen 19–9, prolonged operation time, increased intraoperative bleeding, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy. Multivariate analysis identified an AAC volume ≥ 312 mm3, prolonged operation time, lymph node metastasis, poor differentiation, and absence of adjuvant chemotherapy as independent OS risk factors. The OS rate was significantly lower in the high AAC group than in the low AAC group. Conclusion: The AAC volume may serve as a preoperative prognostic indicator for patients with pancreatic cancer.
KW - Abdominal aortic calcification
KW - Atherosclerosis
KW - Chronic inflammation
KW - Pancreatic cancer
KW - Prognostic score
UR - http://www.scopus.com/inward/record.url?scp=85196036496&partnerID=8YFLogxK
U2 - 10.1007/s00595-024-02882-2
DO - 10.1007/s00595-024-02882-2
M3 - 学術論文
C2 - 38880804
AN - SCOPUS:85196036496
SN - 0941-1291
JO - Surgery Today
JF - Surgery Today
ER -
