TY - JOUR
T1 - A Novel Mechanism for Bone Loss
T2 - Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL
AU - Kikuchi, Shohei
AU - Wada, Akinori
AU - Kamihara, Yusuke
AU - Yamamoto, Imari
AU - Kirigaya, Daiki
AU - Kunimoto, Kohei
AU - Horaguchi, Ryusuke
AU - Fujihira, Takuma
AU - Nabe, Yoshimi
AU - Minemura, Tomoki
AU - Dang, Nam H.
AU - Sato, Tsutomu
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biological factors linking the two are largely unknown. In our present study, we found no clear association between platelet count and BMD in the female group, with aging having a very strong effect on BMD. On the other hand, a significant negative correlation was found between platelet count and BMD in the male group. As a potential mechanism, we examined whether megakaryocytes, the source of platelet production, secrete cytokines that regulate BMD, namely OPG, M-CSF, and RANKL. We detected the production of these cytokines by megakaryocytes derived from bone marrow mononuclear cells, and found that RANKL was negatively correlated with BMD. This finding suggests that RANKL production by megakaryocytes may mediate the negative correlation between platelet count and BMD. To our knowledge, this is the first report to analyze bone marrow cells as a mechanism for the association between blood count and BMD. Our study may provide new insights into the development and potential treatment of osteoporosis.
AB - A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biological factors linking the two are largely unknown. In our present study, we found no clear association between platelet count and BMD in the female group, with aging having a very strong effect on BMD. On the other hand, a significant negative correlation was found between platelet count and BMD in the male group. As a potential mechanism, we examined whether megakaryocytes, the source of platelet production, secrete cytokines that regulate BMD, namely OPG, M-CSF, and RANKL. We detected the production of these cytokines by megakaryocytes derived from bone marrow mononuclear cells, and found that RANKL was negatively correlated with BMD. This finding suggests that RANKL production by megakaryocytes may mediate the negative correlation between platelet count and BMD. To our knowledge, this is the first report to analyze bone marrow cells as a mechanism for the association between blood count and BMD. Our study may provide new insights into the development and potential treatment of osteoporosis.
KW - RANKL
KW - bone mineral density
KW - megakaryocyte
KW - platelet
UR - http://www.scopus.com/inward/record.url?scp=85167895361&partnerID=8YFLogxK
U2 - 10.3390/ijms241512150
DO - 10.3390/ijms241512150
M3 - 学術論文
C2 - 37569526
AN - SCOPUS:85167895361
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 15
M1 - 12150
ER -