A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Nhat Nam Hoang; Takeshi Kodama; Nwet Nwet Win; Prema; Kiep Minh Do; Ikuro Abe; Hiroyuki Morita

doi:10.1002/cbdv.202100401

A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Nhat Nam Hoang, Takeshi Kodama, Nwet Nwet Win, Prema, Kiep Minh Do, Ikuro Abe, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

Original language	English
Article number	e2100401
Journal	Chemistry and Biodiversity
Volume	18
Issue number	10
DOIs	https://doi.org/10.1002/cbdv.202100401
State	Published - 2021/10

Keywords

Alpinia galanga
Viral protein R
monoterpene
sesquiterpene

ASJC Scopus subject areas

Bioengineering
Biochemistry
General Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbdv.202100401

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title = "A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity",

abstract = "A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.",

keywords = "Alpinia galanga, Viral protein R, monoterpene, sesquiterpene",

author = "{Nam Hoang}, Nhat and Takeshi Kodama and {Nwet Win}, Nwet and Prema and {Minh Do}, Kiep and Ikuro Abe and Hiroyuki Morita",

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doi = "10.1002/cbdv.202100401",

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AU - Nam Hoang, Nhat

AU - Kodama, Takeshi

AU - Nwet Win, Nwet

AU - Prema,

AU - Minh Do, Kiep

AU - Abe, Ikuro

AU - Morita, Hiroyuki

PY - 2021/10

Y1 - 2021/10

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AB - A new menthane-type monoterpene, alpigalanol (1), together with four known terpenes (2–5) were isolated from the ethyl acetate soluble fraction of the 70 % ethanol extract of the Alpinia galanga rhizomes. The structure of 1 was determined by spectroscopic analyses, including 1D- and 2D-NMR. The extract of the A. galanga rhizomes and all isolated compounds (1–5) possessed Vpr inhibitory activities against the TREx-HeLa-Vpr cells at a concentration of 1.25 μM without showing any cytotoxicity.

KW - Alpinia galanga

KW - Viral protein R

KW - monoterpene

KW - sesquiterpene

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SN - 1612-1872

VL - 18

JO - Chemistry and Biodiversity

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A New Monoterpene from the Rhizomes of Alpinia galanga and Its Anti-Vpr Activity

Abstract

Keywords

ASJC Scopus subject areas

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