TY - JOUR
T1 - A new caffeic acid ester and a new ceramide from the roots of Eriosema glomeratum
AU - Tabakam, Gaétan Tchangou
AU - Kodama, Takeshi
AU - Donfack, Arno Rusel Nanfack
AU - Nguekeu, Yves Martial Mba
AU - Nomin-Erdene, Battsengel
AU - Htoo, Zin Paing
AU - Do, Kiep Minh
AU - Ngouela, Silvère Augustin
AU - Tene, Mathieu
AU - Morita, Hiroyuki
AU - Awouafack, Maurice Ducret
N1 - Publisher Copyright:
© 2021 Phytochemical Society of Europe
PY - 2021/10
Y1 - 2021/10
N2 - A new caffeic acid ester, eriocaffeate (1), and a new ceramide, erioceramide (2) along with eight known compounds, genistein (3), genistin (4), lupinisoflavone A (5), quercetin (6), lupeol (7), a mixture of β-sitosterol (8) and stigmasterol (9), and β-sitosterol-3-O-β-D-glucopyranoside (10) were obtained after the phytochemical investigation of the CH2Cl2/MeOH (1:1, v/v) extract from the roots of Eriosema glomeratum. The structures of the new compounds were elucidated by analyses of their spectroscopic data including 1D- and 2D-NMR, HRESI-MS, and ESI-MS/MS as well as chemical conversions. The cytotoxicity of isolated compounds 1−6 was determined against three human [lung (A549), breast (MCF7), and cervical (HeLa)] cancer cell lines. Compounds 3 and 6 possessed the activities on all the tested three cell lines, MCF7 (IC50 = 88.9 and 42.6 μM), A549 (IC50 = 42.1 and 28.2 μM), and HeLa (IC50 = 27.4 and 19.1 μM), respectively. Compound 4 showed selective moderate activity with the IC50 value of 68.7 μM on the HeLa cancer cell line.
AB - A new caffeic acid ester, eriocaffeate (1), and a new ceramide, erioceramide (2) along with eight known compounds, genistein (3), genistin (4), lupinisoflavone A (5), quercetin (6), lupeol (7), a mixture of β-sitosterol (8) and stigmasterol (9), and β-sitosterol-3-O-β-D-glucopyranoside (10) were obtained after the phytochemical investigation of the CH2Cl2/MeOH (1:1, v/v) extract from the roots of Eriosema glomeratum. The structures of the new compounds were elucidated by analyses of their spectroscopic data including 1D- and 2D-NMR, HRESI-MS, and ESI-MS/MS as well as chemical conversions. The cytotoxicity of isolated compounds 1−6 was determined against three human [lung (A549), breast (MCF7), and cervical (HeLa)] cancer cell lines. Compounds 3 and 6 possessed the activities on all the tested three cell lines, MCF7 (IC50 = 88.9 and 42.6 μM), A549 (IC50 = 42.1 and 28.2 μM), and HeLa (IC50 = 27.4 and 19.1 μM), respectively. Compound 4 showed selective moderate activity with the IC50 value of 68.7 μM on the HeLa cancer cell line.
KW - Constituents
KW - Cytotoxicity
KW - Eriosema glomeratum
KW - Fabaceae
KW - Roots
UR - http://www.scopus.com/inward/record.url?scp=85111865952&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2021.07.019
DO - 10.1016/j.phytol.2021.07.019
M3 - 学術論文
AN - SCOPUS:85111865952
SN - 1874-3900
VL - 45
SP - 82
EP - 87
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -