TY - JOUR
T1 - A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating
AU - Suzuki, Akinobu
AU - Kosugi, Sakurako
AU - Murayama, Emi
AU - Sasakawa, Eri
AU - Ohkawa, Noriaki
AU - Konno, Ayumu
AU - Hirai, Hirokazu
AU - Inokuchi, Kaoru
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.
AB - When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.
UR - http://www.scopus.com/inward/record.url?scp=85122816727&partnerID=8YFLogxK
U2 - 10.1038/s41467-021-27763-x
DO - 10.1038/s41467-021-27763-x
M3 - 学術論文
C2 - 35017495
AN - SCOPUS:85122816727
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 41
ER -