5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Atsushi Kato; Izumi Nakagome; Uta Kanekiyo; Tian-Tian Lu; Yi-Xian Li; Kosuke Yoshimura; Mana Kishida; Kenta Shinzawa; Tomoki Yoshida; Nobutada Tanaka; Yue-Mei Jia; Robert J. Nash; George W. J. Fleet; Chu-Yi Yu

doi:10.1021/acs.jmedchem.1c01673

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Translated title of the contribution: 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Atsushi Kato, Izumi Nakagome, Uta Kanekiyo, Tian-Tian Lu, Yi-Xian Li, Kosuke Yoshimura, Mana Kishida, Kenta Shinzawa, Tomoki Yoshida, Nobutada Tanaka, Yue-Mei Jia, Robert J. Nash, George W. J. Fleet, Chu-Yi Yu

Hospital Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Translated title of the contribution	5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease
Original language	English
Pages (from-to)	2329-2341
Number of pages	13
Journal	Journal of Medicinal Chemistry
Volume	65
Issue number	3
DOIs	https://doi.org/10.1021/acs.jmedchem.1c01673
State	Published - 2022/02/10

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Kato, A., Nakagome, I., Kanekiyo, U., Lu, T.-T., Li, Y.-X., Yoshimura, K., Kishida, M., Shinzawa, K., Yoshida, T., Tanaka, N., Jia, Y.-M., Nash, R. J., Fleet, G. W. J., & Yu, C.-Y. (2022). 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease. Journal of Medicinal Chemistry, 65(3), 2329-2341. https://doi.org/10.1021/acs.jmedchem.1c01673

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title = "5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease",

author = "Atsushi Kato and Izumi Nakagome and Uta Kanekiyo and Tian-Tian Lu and Yi-Xian Li and Kosuke Yoshimura and Mana Kishida and Kenta Shinzawa and Tomoki Yoshida and Nobutada Tanaka and Yue-Mei Jia and Nash, {Robert J.} and Fleet, {George W. J.} and Chu-Yi Yu",

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doi = "10.1021/acs.jmedchem.1c01673",

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Kato, A, Nakagome, I, Kanekiyo, U, Lu, T-T, Li, Y-X, Yoshimura, K, Kishida, M, Shinzawa, K, Yoshida, T, Tanaka, N, Jia, Y-M, Nash, RJ, Fleet, GWJ & Yu, C-Y 2022, '5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease', Journal of Medicinal Chemistry, vol. 65, no. 3, pp. 2329-2341. https://doi.org/10.1021/acs.jmedchem.1c01673

TY - JOUR

T1 - 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

AU - Kato, Atsushi

AU - Nakagome, Izumi

AU - Kanekiyo, Uta

AU - Lu, Tian-Tian

AU - Li, Yi-Xian

AU - Yoshimura, Kosuke

AU - Kishida, Mana

AU - Shinzawa, Kenta

AU - Yoshida, Tomoki

AU - Tanaka, Nobutada

AU - Jia, Yue-Mei

AU - Nash, Robert J.

AU - Fleet, George W. J.

AU - Yu, Chu-Yi

PY - 2022/2/10

Y1 - 2022/2/10

U2 - 10.1021/acs.jmedchem.1c01673

DO - 10.1021/acs.jmedchem.1c01673

M3 - 学術論文

C2 - 35072486

SN - 0022-2623

VL - 65

SP - 2329

EP - 2341

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 3

ER -