Project Details
Description
Genome-wide screening of array-based comparative genomic hybridization (array CGH) was used to investigate bone and soft tissue tumors. Our results may provide several entry points for the identification of candidate genes associated with aggressive change. Especially, the locus 17p11-13 including HIC1 close to p53 was common high amplification in this series. When human MOS cells are treated with 3mM dbcAMP for 24 hours, apoptotic changes were showed. From the finding of array CGH, amplification of SHGC17327 and LLGL1 and loss of OCRL1 are detected in the treated MOS cells.We found the apoptotic changes of osteosarcoma cells in response to flavonol and flavanol in the screening examination of 11 flavonoids. In particular, ECG and EGCG induced sub-G1 increase, positivity of Anexin V, activation of caspase-3. ECG and EGCG with gallate-substrate provided the anti-proliferative effects that were stronger than any other catechins.
Status | Finished |
---|---|
Effective start/end date | 2010/04/01 → 2014/03/31 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.