Projects per year
Personal profile
Campus career
薬学科 准教授 2009/10/01-2019/09/30
展開ゲノム薬学系 准教授 2009/10/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
展開ゲノム薬学系 准教授 2009/10/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research Fields, Keywords
- Molecular Biology
Field of expertise (Grants-in-aid for Scientific Research classification)
- Molecular biology
- Cell biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Regulation of mRNA metabolism by the transcription-coupled RNA methyltransferase PCIF1
Hirose, Y. (PI)
2017/04/01 → 2020/03/31
Project: Research
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Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity
Sugita, A., Kano, R., Ishiguro, H., Yanagisawa, N., Kuruma, S., Wani, S., Tanaka, A., Tabuchi, Y., Ohkuma, Y. & Hirose, Y., 2024/10, In: Cells. 13, 20, 1689.Research output: Contribution to journal › Article › peer-review
Open Access -
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants
Zarate, Y. A., Uehara, T., Abe, K., Oginuma, M., Harako, S., Ishitani, S., Lehesjoki, A. E., Bierhals, T., Kloth, K., Ehmke, N., Horn, D., Holtgrewe, M., Anderson, K., Viskochil, D., Edgar-Zarate, C. L., Sacoto, M. J. G., Schnur, R. E., Morrow, M. M., Sanchez-Valle, A. & Pappas, J. & 14 others, , 2021/06, In: Genetics in Medicine. 23, 6, p. 1050-1057 8 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
The cap-specific m6A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner
Sugita, A., Kuruma, S., Yanagisawa, N., Ishiguro, H., Kano, R., Ohkuma, Y. & Hirose, Y., 2021/08/01, In: Journal of Biochemistry. 170, 2, p. 203-213 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase
Akichika, S., Hirano, S., Shichino, Y., Suzuki, T., Nishimasu, H., Ishitani, R., Sugita, A., Hirose, Y., Iwasaki, S., Nureki, O. & Suzuki, T., 2019/01/11, In: Science. 363, 6423, eaav0080.Research output: Contribution to journal › Article › peer-review
Open Access272 Scopus citations -
Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9
Yamamoto, S., Hagihara, T., Horiuchi, Y., Okui, A., Wani, S., Yoshida, T., Inoue, T., Tanaka, A., Ito, T., Hirose, Y. & Ohkuma, Y., 2017/03/01, In: Genes to Cells. 22, 3, p. 265-276 12 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations
Datasets
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Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00006irz
Dataset
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Crystal structure of the human cap-specific adenosine methyltransferase
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRV/pdb, https://www.wwpdb.org/pdb?id=pdb_00006irv
Dataset
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Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRY/pdb, https://www.wwpdb.org/pdb?id=pdb_00006iry
Dataset
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Crystal structure of the zebrafish cap-specific adenosine methyltransferase bound to SAH and m7G-capped RNA
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IS0/pdb, https://www.wwpdb.org/pdb?id=pdb_00006is0
Dataset
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Crystal structure of the human cap-specific adenosine methyltransferase bound to SAH
Akichika, S. (Contributor), Hirano, S. (Contributor), Shichino, Y. (Contributor), Suzuki, T. (Contributor), Nishimasu, H. (Contributor), Ishitani, R. (Contributor), Sugita, A. (Contributor), Hirose, Y. (Contributor), Iwasaki, S. (Contributor), Nureki, O. (Contributor) & Suzuki, T. (Contributor), Protein Data Bank (PDB), 2018/12/05
DOI: 10.2210/pdb6IRW/pdb, https://www.wwpdb.org/pdb?id=pdb_00006irw
Dataset
Courses
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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先端生命薬学
Tabuchi, A., Hirose, Y., Morita, M., Kuniishi, M., Tanaka, A., So, T., Ihara, D., Yokoyama, S. & Sakurai, H. 2024/10/01 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course