Yu Nakashima

2025

Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana

Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity

Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis

Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases

Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes

Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities

Hoang, N. N., Hoshino, S., Kodama, T., Nakashima, Y., Do, K. M., Thao, H. X., Ikumi, N., Onaka, H. & Morita, H., 2024/06, In: Chemical and Pharmaceutical Bulletin. 72, 6, p. 540-546 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2023

5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5

Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 2023/08/10, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes

Hoang, N. N., Kodama, T., Nakashima, Y., Do, K. M., Hnin, S. Y. Y., Lee, Y. E., Prema, Ikumi, N. & Morita, H., 2023/09, In: Natural Medicines. 77, 4, p. 891-897 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Phenolic Derivatives with Anti-Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam

Do, K. M., Nakashima, Y., Kodama, T., Lee, Y. E., Nguyen, H. M., Ikumi, N. & Morita, H., 2023/12, In: Chemistry and Biodiversity. 20, 12, e202301482.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2

Figg, W. D., Fiorini, G., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2023/11, In: Proteins: Structure, Function and Genetics. 91, 11, p. 1510-1524 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

Corner, T. P., Teo, R. Z. R., Wu, Y., Salah, E., Nakashima, Y., Fiorini, G., Tumber, A., Brasnett, A., Holt-Martyn, J. P., Figg, W. D., Zhang, X., Brewitz, L. & Schofield, C. J., 2023/10/27, In: Chemical Science. 14, 43, p. 12098-12120 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism

Nakashima, Y., Kawakami, A., Ogasawara, Y., Maeki, M., Tokeshi, M., Dairi, T. & Morita, H., 2023/12, In: Nature Communications. 14, 1, 4752.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2022

Catalytic potential of a fungal indole prenyltransferase toward β-carbolines, harmine and harman, and their prenylation effects on antibacterial activity

Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X. & Morita, H., 2022/10, In: Journal of Bioscience and Bioengineering. 134, 4, p. 311-317 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.

Research output: Contribution to journal › Article › peer-review

Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase

Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X., Matsui, T. & Morita, H., 2022/09, In: Natural Medicines. 76, 4, p. 873-879 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

Wang, X. H., Gao, B. W., Nakashima, Y., Mori, T., Zhang, Z. X., Kodama, T., Lee, Y. E., Zhang, Z. K., Wong, C. P., Liu, Q. Q., Qi, B. W., Wang, J., Li, J., Liu, X., Abe, I., Morita, H., Tu, P. F. & Shi, S. P., 2022/12, In: Nature Communications. 13, 1, 348.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Structure, function, and engineering of plant polyketide synthases

Mori, T., Nakashima, Y., Morita, H. & Abe, I., 2022/01, Biochemical Pathways and Environmental Responses in Plants: Part A. Jez, J. (ed.). Academic Press Inc., p. 3-48 46 p. (Methods in Enzymology; vol. 676).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Mori, T., Nakashima, Y., Chen, H., Hoshino, S., Mitsuhashi, T. & Abe, I., 2022/04/11, In: Chemical Communications. 58, 36, p. 5510-5513 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2021

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

Nakashima, Y., Brewitz, L., Tumber, A., Salah, E. & Schofield, C. J., 2021/12, In: Nature Communications. 12, 1, 6478.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

Brewitz, L., Nakashima, Y., Tumber, A., Salah, E. & Schofield, C. J., 2021/07, In: Journal of Fluorine Chemistry. 247, 109804.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Human Oxygenase Variants Employing a Single Protein Fe^II Ligand Are Catalytically Active

Brasnett, A., Pfeffer, I., Brewitz, L., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2021/06/21, In: Angewandte Chemie - International Edition. 60, 26, p. 14657-14663 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat

Figg, W. D., McDonough, M. A., Chowdhury, R., Nakashima, Y., Zhang, Z., Holt-Martyn, J. P., Krajnc, A. & Schofield, C. J., 2021/07/06, In: ChemMedChem. 16, 13, p. 2082-2088 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

Brewitz, L., Nakashima, Y. & Schofield, C. J., 2021/01/28, In: Chemical Science. 12, 4, p. 1327-1342 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2020

A human protein hydroxylase that accepts D-residues

Choi, H., Hardy, A. P., Leissing, T. M., Chowdhury, R., Nakashima, Y., Ge, W., Markoulides, M., Scotti, J. S., Gerken, P. A., Thorbjornsrud, H., Kang, D., Hong, S., Lee, J., McDonough, M. A., Park, H. & Schofield, C. J., 2020/12/01, In: Communications Chemistry. 3, 1, 52.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2018

A tryptophan prenyltransferase with broad substrate tolerance from bacillus subtilis subsp. Natto

Sugita, T., Okada, M., Nakashima, Y., Tian, T. & Abe, I., 2018/07/04, In: ChemBioChem. 19, 13, p. 1396-1399 4 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Molecular Insight into the Mg²⁺-Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1

Awakawa, T., Mori, T., Nakashima, Y., Zhai, R., Wong, C. P., Hillwig, M. L., Liu, X. & Abe, I., 2018/06/04, In: Angewandte Chemie - International Edition. 57, 23, p. 6810-6813 4 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis

Nakashima, Y., Mitsuhashi, T., Matsuda, Y., Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T. & Abe, I., 2018/08/01, In: Journal of the American Chemical Society. 140, 30, p. 9743-9750 8 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T. & Abe, I., 2018/12/01, In: Nature Communications. 9, 1, 104.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3

Wong, C. P., Awakawa, T., Nakashima, Y., Mori, T., Zhu, Q., Liu, X. & Abe, I., 2018/01/08, In: Angewandte Chemie - International Edition. 57, 2, p. 560-563 4 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2016

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

Matsuda, Y., Iwabuchi, T., Fujimoto, T., Awakawa, T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F. & Abe, I., 2016/09/28, In: Journal of the American Chemical Society. 138, 38, p. 12671-12677 7 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'entotheonella'

Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T. & Abe, I., 2016/10, In: PLoS ONE. 11, 10, e0164468.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme

Okada, M., Sugita, T., Akita, K., Nakashima, Y., Tian, T., Li, C., Mori, T. & Abe, I., 2016, In: Organic and Biomolecular Chemistry. 14, 40, p. 9639-9644 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2014

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto, Y., Mori, T., Awakawa, T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J. & Abe, I., 2014/08, In: Nature Chemical Biology. 10, 8, p. 648-655 8 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Yu Nakashima

Research output

Search results