Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 助教 2021/01/01-
薬学・和漢系 助教 2021/01/01-
薬学・和漢系 助教 2021/01/01-
Research Fields, Keywords
- Natural product
- X-ray crystallography
Field of expertise (Grants-in-aid for Scientific Research classification)
- Natural medicines
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Dive into the research topics where Yu Nakashima is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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MAFLD治療を指向した伝統生薬由来FIH非キレート阻害剤の探索
Nakashima, Y. (Principal Investigator)
Japan Society for the Promotion of Science
2026/04/01 → 2029/03/31
Project: Research Project
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神経軸索伸長活性アルカロイドの創出を指向したアルカロイド生合成酵素の機能改変
Morita, H. (Principal Investigator) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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Functional analysis and engineering of biosynthetic enzymes for the formation of Alkaloid scaffold with AchE inhibitory activity.
Morita, H. (Principal Investigator), Kodama, T. (Co-Investigator(Kenkyū-buntansha)) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2025/03/31
Project: Research Project
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FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索
Nakashima, Y. (Principal Investigator)
Japan Society for the Promotion of Science
2024/04/01 → 2026/03/31
Project: Research Project
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AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変
Morita, H. (Principal Investigator), Kodama, T. (Co-Investigator(Kenkyū-buntansha)) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges
Dell, M., Kogawa, M., Streiff, A. B., Shiraishi, T., Lotti, A., Meier, C. M., Schorn, M. A., Field, C., Cahn, J. K. B., Yokoyama, H., Yamada, Y., Peters, E., Egami, Y., Nakashima, Y., Tan, K. C., Rückert, C., Alanjary, M., Kalinowski, J., Kuzuyama, T. & Cardenas, P. & 8 others, , 2026/02, In: Nature Chemical Biology. 22, 2, p. 217-228 12 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Multi-omics dissection of steviol glycoside synthesis reveals haplotype-linked specialization of UGT76G genes in Stevia rebaudiana
Shoji, T., Fukushima, A., Morinaka, H., Takagi, H., Nakashima, Y., Mori, T., Kawamura, A., Shi, D., Torii, K., Iwase, A., Takeda-Kamiya, N., Toyooka, K., Morita, H., Hirai, M. Y., Sugimoto, K., Saito, K. & Hirai, T., 2026/07, In: New Phytologist. 251, 1, p. 384-404 21 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Structural Basis of Starter-Substrate Selectivity Governed by a Single Residue in Orcinol Synthase
Nakashima, Y., Hnin, S. Y. Y., Kim, S., Byeon, H., Vimolmangkang, S. & Morita, H., 2026, In: Chemical and Pharmaceutical Bulletin. 74, 7, p. 591-597 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-Guided Engineering of 2-Oxoglutarate-Dependent Oxygenases: Principles, Case Studies, and Emerging Opportunities
Nakashima, Y., 2026/01/01, In: Chemical and Pharmaceutical Bulletin. 74, 1, p. 1-15 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
tRNA-Dependent Chemoenzymatic Transformation of Aminoacyl Pendant Moieties of Streptothricin Antibiotics
Maruyama, C., Nakashima, Y., Matsuda, K., A. Hamdy, S., Uchiyama, S., Goto, Y., Mori, T., Ogasawara, Y., Shin-ya, K., Abe, I., Dairi, T., Suga, H., Morita, H. & Hamano, Y., 2026/03/25, In: Journal of the American Chemical Society. 148, 11, p. 12154-12165 12 p.Research output: Contribution to journal › Article › peer-review
Datasets
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Aspartyl/Asparaginyl beta-hydroxylase (AspH) H725A in complex with Factor X peptide fragment (39mer-4Ser)
Brasnett, A. (Contributor), Pfeffer, I. (Contributor), Brewitz, L. (Contributor), Chowdhury, R. (Contributor), Nakashima, Y. (Contributor), Tumber, A. (Contributor), McDonough, M. A. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/06/30
DOI: 10.2210/pdb7E6J/pdb, https://www.wwpdb.org/pdb?id=pdb_00007e6j
Dataset
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Nakashima, Y. (Contributor), Brewitz, L. (Contributor), Tumber, A. (Contributor), Salah, E. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/08/25
DOI: 10.2210/pdb7A1S/pdb, https://www.wwpdb.org/pdb?id=pdb_00007a1s
Dataset
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Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with olivetolic acid
Lee, Y.-E. (Contributor), Nakashima, Y. (Contributor), Kodama, T. (Contributor), Chen, X. (Contributor) & Morita, H. (Contributor), Protein Data Bank (PDB), 2022/02/02
DOI: 10.2210/pdb7W6D/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w6d
Dataset
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HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-2 ALPHA CODD (523-542)
Figg, W. D. (Contributor), Fiorini, G. (Contributor), Chowdhury, R. (Contributor), Nakashima, Y. (Contributor), Tumber, A. (Contributor), McDonough, M. A. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2022/11/16
DOI: 10.2210/pdb7Q5X/pdb, https://www.wwpdb.org/pdb?id=pdb_00007q5x
Dataset
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-(carboxycarbonyl)cyclopentane-1-carboxylic acid, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Nakashima, Y. (Contributor), Brewitz, L. (Contributor), Tumber, A. (Contributor), Salah, E. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/08/25
DOI: 10.2210/pdb7A1Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007a1q
Dataset
Prizes
Activities
- 4 Oral presentation
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Structural-Based Design of Selective Enhancement or Inhibition of Human 2-Oxoglutarate Dependent Oxygenases
Nakashima, Y. (Speaker)
2022/06/12Activity: Talk or presentation › Oral presentation
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抗生物質 glycylthricin 生合成酵素に見られる基質特異性の解明
Nakashima, Y. (Speaker)
2022/03/25 → 2022/03/28Activity: Talk or presentation › Oral presentation
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2-オキソグルタル酸依存性酸化酵素の選択的阻害剤の開発
Nakashima, Y. (Speaker)
2022/01/27Activity: Talk or presentation › Oral presentation
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X 線結晶構造解析に基づく抗生物質 glycylthricin 生合成酵素に見られる基質特異性の解明
Nakashima, Y. (Speaker)
2021/11/14Activity: Talk or presentation › Oral presentation
Courses
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T., Akagi, K., Manse, Y. & Araki, M. 2025/04/01 → 2025/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T., Akagi, K., Manse, Y. & Araki, M. 2025/04/01 → 2025/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T., Akagi, K., Manse, Y. & Araki, M. 2025/04/01 → 2025/09/30
Course
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東西医薬学Ⅰ
Kato, A., Watanabe, S., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J., Oku, M., Jo, M., Sasaki, S., Nakashima, Y. & Shoji, T. 2025/04/01 → 2025/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T. & Akagi, K. 2025/04/01 → 2025/09/30
Course