Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 准教授 2012/04/01-2017/03/31
和漢医薬学総合研究所 教授 2017/04/01-2019/09/30
薬学・和漢系 教授 2019/10/01-
和漢医薬学総合研究所 教授 2019/10/01-
和漢医薬学総合研究所 教授 2017/04/01-2019/09/30
薬学・和漢系 教授 2019/10/01-
和漢医薬学総合研究所 教授 2019/10/01-
Research interests
病態における自然免疫応答の役割解明と創薬への応用
1)NK細胞のバイオロジーと腫瘍免疫応答における役割
2)がん病態進展における腫瘍微小環境での自然免疫応答の役割
3)がんモデルにおける病態のリアルタイムイメージング
4) 和漢薬による免疫疾患制御
1)NK細胞のバイオロジーと腫瘍免疫応答における役割
2)がん病態進展における腫瘍微小環境での自然免疫応答の役割
3)がんモデルにおける病態のリアルタイムイメージング
4) 和漢薬による免疫疾患制御
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fields, Keywords
- Cancer
- Immunology
- Inflammation
- metastasis
- Host defenses
- Natural Killer cell
Field of expertise (Grants-in-aid for Scientific Research classification)
- Oncology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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老化線維芽細胞制御によるがん休眠細胞の封じ込めによる骨転移治療法の開発
Hayakawa, Y. (Principal Investigator)
Japan Society for the Promotion of Science
2025/06/27 → 2027/03/31
Project: Research Project
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Elucidation of the exhaustion process of NK cells in tumor
Hayakawa, Y. (Principal Investigator) & 山口哲志 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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SOX10 regulates melanoma heterogeneity
Yokoyama, S. (Principal Investigator), Hayakawa, Y. (Co-Investigator(Kenkyū-buntansha)) & Hayashi, R. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Allosteric SHP2 inhibitors suppress lung cancer cell migration by inhibiting non-canonical activation of EphA2 via the ERK-RSK signaling pathway
Nguyen, K., Zhou, Y., Yokoyama, S., Sasaki, S. I., Yano, S., Hayashi, R., Koizumi, K., Hayakawa, Y. & Sakurai, H., 2025/12, In: Scientific Reports. 15, 1, 36926.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of anti-asialo-GM1 monoclonal antibody
He, K., Kimura, T., Takeda, K. & Hayakawa, Y., 2025/01, In: Biochemical and Biophysical Research Communications. 743, 151197.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dihydrocapsaicin Enhances Tumor Necrosis Factor-α-Induced Apoptosis and G1 Cell Cycle Arrest in Human Cervical Cancer Cells Through TAK1-Mediated NF-κB and EGFR Pathways
Boonyarat, C., Sakurai, H., Hayakawa, Y., Chaiwiwatrakul, S., Kaewamatawong, R., Supapaan, T. S., Duangjit, S., Sethabouppha, B. & Waiwut, P., 2025/06, In: International Journal of Molecular Sciences. 26, 11, 5011.Research output: Contribution to journal › Article › peer-review
Open Access -
PP2A negatively regulates NK cell T-bet expression and anti-tumor effector function
Shinzawa, Y., Hara, D., Shinguryo, Y., Yokoyama, S., Kawada, M. & Hayakawa, Y., 2025/02/01, In: International Immunology. 37, 2, p. 97-107 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Preferential Recognition of Drug-Induced Altered Self-Presentation on Tumor Cells, but Not Host Cells, by CD8+ T Cells for Eliciting Anti-Tumor Immunity
Susukida, T., Aoki, S. & Hayakawa, Y., 2025/10/23, In: Biological and Pharmaceutical Bulletin. 48, 10, p. 1566-1571 6 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5371306, https://springernature.figshare.com/collections/Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/5371306
Dataset
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Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5371306.v1, https://springernature.figshare.com/collections/Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/5371306/1
Dataset
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Additional file 2 of Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14396845.v1, https://springernature.figshare.com/articles/presentation/Additional_file_2_of_Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/14396845/1
Dataset
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Additional file 2 of Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14396845, https://springernature.figshare.com/articles/presentation/Additional_file_2_of_Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/14396845
Dataset
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SARS-CoV-2 spike RBD in complex with neutralizing antibody UT28K
Ozawa, T. (Contributor), Tani, H. (Contributor), Anraku, Y. (Contributor), Kita, S. (Contributor), Igarashi, E. (Contributor), Saga, Y. (Contributor), Inasaki, N. (Contributor), Kawasuji, H. (Contributor), Yamada, H. (Contributor), Sasaki, S.-I. (Contributor), Somekawa, M. (Contributor), Sasaki, J. (Contributor), Hayakawa, Y. (Contributor), Yamamoto, Y. (Contributor), Morinaga, Y. (Contributor), Kurosawa, N. (Contributor), Isobe, M. (Contributor), Fukuhara, H. (Contributor), Maenaka, K. (Contributor), Hashiguchi, T. (Contributor), Kishi, H. (Contributor), Kitajima, I. (Contributor), Saito, S. (Contributor) & Niimi, H. (Contributor), Protein Data Bank (PDB), 2022/05/25
DOI: 10.2210/pdb7X7O/pdb, https://www.wwpdb.org/pdb?id=pdb_00007x7o
Dataset
Prizes
Activities
- 27 Oral presentation
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Resveratrol induces apoptosis in melanoma cells via downregulation of survivin expression.
Hayakawa, Y. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
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Role of cross- talk between host immune responses and cancer cells in metastasis disease
Hayakawa, Y. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
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Requirement of CD4+ T cells for establishing inflammatory tumor microenvironment in 4T1 breast cancer model.
Hayakawa, Y. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
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Mesenchymal-transitioned cancer cells instigate surrounding cancer cells to metastasis via secretion of WNT ligands
Hayakawa, Y. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
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Cross-talk between host and cancer cells amplify inflammation triggered by gdT17 cells to promote malignant progression.
Hayakawa, Y. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
Courses
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応用和漢医薬学特論
Watanabe, S., Tohda, C., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J. & Oku, M. 2024/12/04 → 2025/03/31
Course
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専門英語Ⅱ（生体防御学領域）
Sakurai, H., Watanabe, S., Hayakawa, Y., Susukida, T. & Sasaki, S. 2024/10/01 → 2025/03/31
Course
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医薬品薬効動態学実習
Hosoya, K.-I., Tabuchi, A., Nitta, A., Sasaoka, T., Hashimoto, Y., To, H., Akanuma, S.-I., So, T., Kume, T., Sakurai, H., Watanabe, S., Shibahara, N., Tohda, C., Koizumi, K., Hayakawa, Y., Nakagawa, Y. & Kim, J. 2024/10/01 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course