Personal profile
Related info
Campus career
臨床薬科学系 講師 2013/05/01-2019/09/30
薬学・和漢系 講師 2019/10/01-
薬学科 講師 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research biography
肝特異的SREBP1c過剰発現マウスを用いた新規非アルコール性脂肪肝炎（NASH）モデルの 作成と、MR阻害剤による肝線維化抑制作用と糖脂質代謝改善作用の検討 科学研究費補助金 期間：2009/04－2013/10
Qualification
Affiliated academic society
日本糖尿病学会 所属期間：1995/11-
日本内分泌学会 所属期間：1998/04-
日本産科婦人科学会 所属期間：2010/10-
Research interests
全身の代謝は中枢神経系を中心とし,肝臓,脂肪などの各末梢組織と機能的な連携をとりながら調節されていることから,これらの臓器連携に影響をおよぼす新たな作用を見出し,特にインスリン抵抗性と関連が深い脂肪組織の肥大化と慢性炎症の進展抑制に着目した研究に取り組んでおります.
また我々が同定したSHIP2がインスリンシグナルを負に制御することから,共同研究を通じてインスリン抵抗性を改善する新規SHIP2阻害剤の開発に向けた創薬研究も行っています.
Education/Academic qualification
M.D., Ph.D.
Field of expertise (Grants-in-aid for Scientific Research classification)
- Metabolomics
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Collaborations and top research areas from the last five years
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脂肪組織の可塑性メモリーを規定するエピゲノム制御による肥満リバウンド抑止法の開発
Wada, T. (Principal Investigator), Sasaoka, T. (Co-Investigator(Kenkyū-buntansha)), Tsuneki, H. (Co-Investigator(Kenkyū-buntansha)) & Onogi, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2028/03/31
Project: Research Project
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Development of a novel treatment for diabetes and depression by promoting olfactory and orexin system
Sasaoka, T. (Principal Investigator), Tsuneki, H. (Co-Investigator(Kenkyū-buntansha)) & Wada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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飽食病態改善のための「嗅覚」刺激を介した飢餓対応型代謝の活用と脂質利用の拡大
Tsuneki, H. (Principal Investigator), Sasaoka, T. (Co-Investigator(Kenkyū-buntansha)) & Wada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2026/03/31
Project: Research Project
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Dynamical network biomarker analysis using multi-organ RNA sequencing in metabolic syndrome model mice
Oku, M., Inujima, A., Koizumi, K., Akagi, K., Fujisaka, S., Wada, T., Onogi, Y., Sasaoka, T., Tobe, K., Kadowaki, M., Shen, X., Imura, J.-I., Aihara, K. & Saito, S., 2026/01/01, In: Nonlinear Theory and Its Applications, IEICE. 17, 1, p. 186-210 25 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Protective role of soluble CD52 in obesity-associated steatotic liver disease and glucose dysregulation in mice
Miyazawa, Y., Wada, T., Iwasa, Y., Fuse, K., Shioneri, H., Onogi, Y., Sameshima, A., Yoshida, T., Takasaki, I., Mori, H., Koizumi, K., Tsuneki, H., Saito, S. & Sasaoka, T., 2026/01, In: Molecular Metabolism. 103, 102279.Research output: Contribution to journal › Article › peer-review
Open Access -
Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism
Tsuneki, H., Maeda, T., Takatsuki, M., Sekine, T., Masui, S., Onishi, K., Takeda, R., Sugiyama, M., Sakurai, T., Yanagisawa, M., Wada, T. & Sasaoka, T., 2025/03, In: PLoS ONE. 20, 3 March, e0320157.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Defective IgG Class Switching in the Spleen of TRAF5-Deficient Mice Reveals a Role for TRAF5 in CD40-Mediated B Cell Responses During Obesity-Associated Inflammation
Wakaizumi, T., Hikosaka-Kuniishi, M., Ozawa, Y., Sato, A., Iwata, C., Wada, T., Sasaoka, T., Morita, M. & So, T., 2025/10, In: International Journal of Molecular Sciences. 26, 19, 9494.Research output: Contribution to journal › Article › peer-review
Open Access -
Olfactory bulbectomy-induced impairment of lipid utilization leads to abnormal glucose metabolism in mice
Sugiyama, M., Tsuneki, H., Onishi, K., Yubune, K., Yamagishi, T., Sano, S., Tanaka, Y., Takasaki, I., Sakurai, T., Yanagisawa, M., Koizumi, K., Kadowaki, M., Saito, S., Wada, T. & Sasaoka, T., 2025/09, In: PLoS ONE. 20, 9 September, e0333176.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Onogi, Y. (Creator), Takeda, Y. (Creator), Sasaoka, T. (Creator), Okekawa, A. (Creator), Sasahara, M. (Creator), Miyazawa, Y. (Creator), Wada, T. (Creator) & Tsuneki, H. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7061173.v1, https://springernature.figshare.com/collections/Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/7061173/1
Dataset
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Additional file 1 of Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Sasaoka, T. (Creator), Onogi, Y. (Creator), Takeda, Y. (Creator), Okekawa, A. (Creator), Sasahara, M. (Creator), Miyazawa, Y. (Creator), Wada, T. (Creator) & Tsuneki, H. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26677148, https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/26677148
Dataset
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A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice
Ikurumi, M. (Creator), Fuse, K. (Creator), Onogi, Y. (Creator), Okekawa, A. (Creator), Wada, T. (Creator), Tsuneki, H. (Creator), Miyazawa, Y. (Creator), Sasaoka, T. (Creator) & Saito, S. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6587371, https://springernature.figshare.com/collections/A_transdermal_treatment_with_MC903_ameliorates_diet-induced_obesity_by_reducing_visceral_fat_and_increasing_myofiber_thickness_and_energy_consumption_in_mice/6587371
Dataset
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A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice
Ikurumi, M. (Creator), Sasaoka, T. (Creator), Saito, S. (Creator), Okekawa, A. (Creator), Fuse, K. (Creator), Tsuneki, H. (Creator), Onogi, Y. (Creator), Miyazawa, Y. (Creator) & Wada, T. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6587371.v1, https://springernature.figshare.com/collections/A_transdermal_treatment_with_MC903_ameliorates_diet-induced_obesity_by_reducing_visceral_fat_and_increasing_myofiber_thickness_and_energy_consumption_in_mice/6587371/1
Dataset
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Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Sasaoka, T. (Creator), Onogi, Y. (Creator), Miyazawa, Y. (Creator), Okekawa, A. (Creator), Tsuneki, H. (Creator), Takeda, Y. (Creator), Sasahara, M. (Creator) & Wada, T. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7061173, https://springernature.figshare.com/collections/Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/7061173
Dataset
Prizes
Activities
- 115 Oral presentation
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脂肪組織肥大化におけるPDGF依存的血管新生の意義
Wada, T. (Speaker)
2015/12/05Activity: Talk or presentation › Oral presentation
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視床下部オレキシンによる自律神経系と小胞体ストレス応答を介したマウス肝糖産生の調節機構．
Wada, T. (Speaker)
2015/12/01 → 2015/12/04Activity: Talk or presentation › Oral presentation
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オレキシン系を標的とした生体リズム制御による2型糖尿病マウスの糖代謝改善効果．
Wada, T. (Speaker)
2015/11/15Activity: Talk or presentation › Oral presentation
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制御性T細胞の性特異的な脂肪組織局在が肥満に伴う慢性炎症と糖代謝に及ぼす影響．
Wada, T. (Speaker)
2015/11/15Activity: Talk or presentation › Oral presentation
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選択的Mineralocorticoid Receptor (MR) 阻害剤エプレレノンによる糖代謝改善機構の解明．
Wada, T. (Speaker)
2015/11/15Activity: Talk or presentation › Oral presentation
Courses
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薬理学特論
Nitta, A., Wada, T., Sasaoka, T., Tsuneki, H., Uta, D., Kume, T. & Kadowaki, M. 2024/12/04 → 2025/03/31
Course
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薬理学特論
Nitta, A., Wada, T., Sasaoka, T., Tsuneki, H., Uta, D., Kume, T. & Kadowaki, M. 2024/04/11 → 2024/06/11
Course
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