Personal profile
Campus career
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
Affiliated academic society
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
Research interests
・立体構造情報を利用した医薬品化学研究
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
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中性子解析に基づく分子標的薬の選択性向上と治療薬開発
Yokoyama, T. (Principal Investigator) & Okada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
Yokoyama, T. (PI)
2019/04/01 → 2022/03/31
Project: Research
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Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomers
Yokoyama, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Neutron Diffraction Analysis of Human Farnesyl Pyrophosphate Synthase in Complex with Bisphosphonate
Yokoyama, T. (PI)
2013/04/01 → 2016/03/31
Project: Research
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Neutron crystallographic analysis of human transthyretin
Yokoyama, T. (PI)
2009/04/01 → 2012/03/31
Project: Research
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Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids
Kagami, A., Hashimoto, N., Sasaki, R., Fukushima, Y., Devkota, H. P., Tanaka, S., Wada, M., Yamanaka, K., Yamakawa, S., Misumi, S., Yokoyama, T., Mizuguchi, M., Sato, T., Nakamura, T., Kotani, S., Suico, M. A., Kai, H., Ueda, M. & Shuto, T., 2026/01/16, In: iScience. 29, 1, 114170.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of FTase inhibitors inspired by the structures of andrastins
Kitamura, F., Tanioka, M., Kosaka, A., Matsuzawa, N., Obita, T., Sakajiri, Y., Shibata, T., Sawada, R., Yokoyama, T., Kohyama, A., Yamada, T., Yamanishi, Y., Mizuguchi, M. & Matsuya, Y., 2025/11, In: Results in Chemistry. 18, 102828.Research output: Contribution to journal › Article › peer-review
Open Access -
Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025/01, Advances in Heterocyclic Chemistry. Scriven, E. F. V. & Ramsden, C. A. (eds.). Academic Press Inc., p. 225-261 37 p. (Advances in Heterocyclic Chemistry; vol. 147).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Scopus citations -
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations
Datasets
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Crystal structure of DAPK1 in complex with genistein.
Yokoyama, T. (Contributor), Kosaka, Y. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2015/10/07
DOI: 10.2210/pdb5AUZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00005auz
Dataset
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Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6
Yokoyama, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2019/03/13
DOI: 10.2210/pdb6IMY/pdb, https://www.wwpdb.org/pdb?id=pdb_00006imy
Dataset
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Crystal structure of MTH1 in apo form (cocktail No. 1)
Yokoyama, T. (Contributor), Kitakami, R. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2019/03/06
DOI: 10.2210/pdb6AA3/pdb, https://www.wwpdb.org/pdb?id=pdb_00006aa3
Dataset
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Crystal structure of H88A mutated human transthyretin
Yokoyama, T. (Contributor), Hanawa, Y. (Contributor), Obita, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2017/06/14
DOI: 10.2210/pdb5H0V/pdb, https://www.wwpdb.org/pdb?id=pdb_00005h0v
Dataset
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Crystal structure of MTH1 in complex with 3-isomangostin
Yokoyama, T. (Contributor), Kitakami, R. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2019/03/06
DOI: 10.2210/pdb6AA5/pdb, https://www.wwpdb.org/pdb?id=pdb_00006aa5
Dataset
Courses
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生物物理学特論
Tomohiro, T., Mizuguchi, M., Obita, T., Yokoyama, T., Nakano, M., Ikeda, K., Nakao, H. & Tanimoto, H. 2023/12/04 → 2024/03/31
Course