Projects per year
Personal profile
Campus career
創薬科学科 助教 2011/06/01-2019/09/30
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
Affiliated academic society
日本生物物理学会 所属期間：2009/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
Research interests
・X線および中性子などの量子ビームを利用した構造生物学
・立体構造情報を利用した医薬品化学研究
・立体構造情報を利用した医薬品化学研究
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 4 Finished
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Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
Yokoyama, T. (PI)
2019/04/01 → 2022/03/31
Project: Research
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Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomers
Yokoyama, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Neutron Diffraction Analysis of Human Farnesyl Pyrophosphate Synthase in Complex with Bisphosphonate
Yokoyama, T. (PI)
2013/04/01 → 2016/03/31
Project: Research
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Neutron crystallographic analysis of human transthyretin
Yokoyama, T. (PI)
2009/04/01 → 2012/03/31
Project: Research
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket
Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.Research output: Contribution to journal › Article › peer-review
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Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
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Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Characterization of the molecular interactions between resveratrol derivatives and death-associated protein kinase 1
Yokoyama, T. & Kusaka, K., 2023/09, In: FEBS Journal. 290, 18, p. 4465-4479 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations