Projects per year
Personal profile
Campus career
創薬科学科 准教授 2010/03/01-2019/09/30
生命分子薬学系 准教授 2010/03/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
創薬科学科 准教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
生命分子薬学系 准教授 2010/03/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
創薬科学科 准教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research Fields, Keywords
- Structural Biology
- Protein Science
Field of expertise (Grants-in-aid for Scientific Research classification)
- Structural biochemistry
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Molecular and structural basis of natural moisturizing factor production mechanisms by profilaggrin-degrading enzymes.
Obita, T. (Principal Investigator)
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
Mizuguchi, M. (Principal Investigator) & Obita, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Structural study of pro-filaggrin recognition by SASPase
Obita, T. (PI)
2020/04/01 → 2023/03/31
Project: Research
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Structural Study of basal transcription factor TFIIE
Obita, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Development of FTase inhibitors inspired by the structures of andrastins
Kitamura, F., Tanioka, M., Kosaka, A., Matsuzawa, N., Obita, T., Sakajiri, Y., Shibata, T., Sawada, R., Yokoyama, T., Kohyama, A., Yamada, T., Yamanishi, Y., Mizuguchi, M. & Matsuya, Y., 2025/11, In: Results in Chemistry. 18, 102828.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and Structural Optimization of a Novel Serine Racemase Inhibitor with a Pyridazine Skeleton
Tozawa, C., Matsukiyo, Y., Oshima, S., Sakajiri, Y., Maeda, C., Shibata, T., Sawada, R., Okada, T., Obita, T., Mizuguchi, M., Mori, H., Yamanishi, Y. & Toyooka, N., 2025/10/06, In: ChemistrySelect. 10, 37, e05651.Research output: Contribution to journal › Article › peer-review
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Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
Etori, H., Asoshina, R., Obita, T. & Okumura, F., 2025/12, In: Scientific Reports. 15, 1, 17913.Research output: Contribution to journal › Article › peer-review
Open Access -
Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations
Datasets
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Crystal structure of I73L mutated human transthyretin
Nakagawa, M. (Contributor), Obita, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2022/11/23
DOI: 10.2210/pdb7WL6/pdb, https://www.wwpdb.org/pdb?id=pdb_00007wl6
Dataset
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Crystal structure of Vps17p PX from S. cerevisiae (Space)
Obita, T. (Contributor), Inaka, K. (Contributor), Kohda, D. (Contributor) & Maita, N. (Contributor), Protein Data Bank (PDB), 2022/05/18
DOI: 10.2210/pdb7X4O/pdb, https://www.wwpdb.org/pdb?id=pdb_00007x4o
Dataset
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Crystal structure of P113A mutated human transthyretin
Yokoyama, T. (Contributor), Hanawa, Y. (Contributor), Obita, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2017/06/14
DOI: 10.2210/pdb5H0Z/pdb, https://www.wwpdb.org/pdb?id=pdb_00005h0z
Dataset
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Crystal structure of H88Y mutated human transthyretin
Yokoyama, T. (Contributor), Hanawa, Y. (Contributor), Obita, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2017/06/14
DOI: 10.2210/pdb5H0Y/pdb, https://www.wwpdb.org/pdb?id=pdb_00005h0y
Dataset
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Crystal structure of the human TFIIE complex
Miwa, K. (Contributor), Kojima, R. (Contributor), Obita, T. (Contributor), Ohkuma, Y. (Contributor), Tamura, Y. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2016/11/02
DOI: 10.2210/pdb5GPY/pdb, https://www.wwpdb.org/pdb?id=pdb_00005gpy
Dataset
Courses
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生物物理学特論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2025/12/05 → 2026/03/31
Course
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生物物理学序論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2025/10/02 → 2025/12/03
Course
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医療分子科学特論
Tomohiro, T., Inouye, M., Mizuguchi, M., Yakura, T., Matsuya, Y., Obita, T., Chiba, J., Nakano, M., Ikeda, K., Lee, J., Tanimoto, H. & Okitsu, T. 2025/10/01 → 2026/03/31
Course
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