Projects per year
Personal profile
Campus career
創薬科学科 准教授 2010/03/01-2019/09/30
生命分子薬学系 准教授 2010/03/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
創薬科学科 准教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
生命分子薬学系 准教授 2010/03/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
創薬科学科 准教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research Fields, Keywords
- Structural Biology
- Protein Science
Field of expertise (Grants-in-aid for Scientific Research classification)
- Structural biochemistry
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Collaborations and top research areas from the last five years
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Projects
- 7 Finished
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Structural study of pro-filaggrin recognition by SASPase
Obita, T. (PI)
2020/04/01 → 2023/03/31
Project: Research
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Structural Study of basal transcription factor TFIIE
Obita, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
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Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis
Mizuguchi, M., Obita, T., Yamada, S. & Nabeshima, Y., 2024/04, In: FEBS Journal. 291, 8, p. 1732-1743 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations