Personal profile
Research biography
The major focus of my research is directed toward the discovery of an "anti-austerity strategy" based on anticancer agents. These agents are useful for the treatment of pancreatic cancer, for which there is no reliable treatment at present. Pancreatic cancers are clinically hypovascular and have inherent tolerance to nutrition starvation. Elimination of this tolerance is a new "Antiausterity strategy" in anticancer drug discovery. Visit the following page for the details. http://nddlab.weebly.com
Laboratory Info
Laboratory Info
For Prospective Graduate Students
We welcome motivated students who wish to pursue careers in natural product chemistry, drug discovery, and drug development. State-of-the-art facilities are available in our lab to conduct advanced research in natural product chemistry, chemical biology, and molecular biology. Each researcher will master the art of isolation and identification of bioactive natural compounds, structure elucidation using the most advanced computer-assisted Nuclear Magnetic Resonance (NMR) spectroscopy technologies, and advanced computational calculations (ECD and NMR). Our laboratory has established a unique NMR strategy based on a chemical biology approach to understand the underlying mechanisms of cancer cells, metabolomes, drug actions, and biomarker discovery. In addition, we investigate the mechanism of action of anticancer drugs against cell survival pathways, with particular emphasis on the PI3K/Akt/mTOR/autophagy pathways.
Our lab has extensive cross-disciplinary scientific collaborations with national and international groups. We welcome enthusiastic students who dream of achieving the highest level of pharmaceutical science, natural medicine, drug discovery, and contributing to better health in human society. We have an excellent research and learning environment and can develop new skills and ideas. Every undergraduate and graduate student in our laboratory can contribute sufficiently to publishing a paper in an international journal with their name as the first author.
Campus career
和漢医薬学総合研究所 准教授 2015/04/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
和漢医薬学総合研究所 准教授 2019/10/01-
Affiliated academic society
Research interests
Research Fields, Keywords
- Drug Discovery
- Pancreatic Cancer
- Cancer Research
- PI3/Akt/mTOR
- Autophagy
- Natural Medicine
- Antiausterity agents
- Screening Strategy
- Nutrition starvation resistance
- Drug resistance
- ECD
- Quantum computational Calculation
- NMR
- Absolute Configuration
- Medicinal Chemistry
- NMR structure elucidation
- Phytochemistry
- Chromatography
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 4 Quality Education
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Collaborations and top research areas from the last five years
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Investigation on naphthylisoquinoline alkaloids as potential antiausterity chemotherapy for pancreatic cancer
Awale, S. (Principal Investigator) & Fujii, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2028/03/31
Project: Research Project
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Discovery of natural anticancer agents that inhibit cancer cells' tolerance to nutrition starvation and elucidation of their molecular mechanisms
Awale, S. (PI)
2016/04/01 → 2020/03/31
Project: Research
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Investigation of pathogenic mechanisms and Kampo medicine-based preventive and therapeutic strategy for ADHD using an epigenetic animal model.
Matsumoto, K. (PI), Awale, S. (CoI), 藤原, 博典 (CoI) & Hori, E. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Search for the antiausterity agents induced metabolomic biomarkers associated with the tolerance of nutrition starvation in pancreatic cancer
Awale, S. (PI) & Esumi, H. (CoI)
2012/04/01 → 2016/03/31
Project: Research
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Development of a new pancreatic cancer curative medicine from arctigenin, an ingredient of Wakan-yaku 'Burdock Fruit (Seeds of Arctium lappa)'
Tezuka, Y. (PI), Toyooka, N. (CoI) & Awale, S. (CoI)
2010/04/01 → 2013/03/31
Project: Research
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Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.Research output: Contribution to journal › Article › peer-review
11 Link opens in a new tab Scopus citations -
New callistrilone epimers from Callistemon citrinus and their antiausterity activity against the PANC-1 human pancreatic cancer cell line
Tawila, A. M., Omar, A. M., Phan, N. D., Takahashi, I., Maneenet, J. & Awale, S., 2022/06/22, In: Tetrahedron Letters. 100, 153881.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line
Tawila, A. M., Sun, S., Kim, M. J., Omar, A. M., Dibwe, D. F., Ueda, J. Y., Toyooka, N. & Awale, S., 2020/08/15, In: Bioorganic and Medicinal Chemistry Letters. 30, 16, 127352.Research output: Contribution to journal › Article › peer-review
24 Link opens in a new tab Scopus citations -
Ancistrolikokine E3, a 5,8′-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway
Awale, S., Dibwe, D. F., Balachandran, C., Fayez, S., Feineis, D., Lombe, B. K. & Bringmann, G., 2018/10/26, In: Journal of Natural Products. 81, 10, p. 2282-2291 10 p.Research output: Contribution to journal › Article › peer-review
71 Link opens in a new tab Scopus citations -
Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
Phan, N. D., Omar, A. M., Sun, S., Maneenet, J., Dibwe, D. F., Sato, M., Kalauni, S. K., Toyooka, N., Fujii, T. & Awale, S., 2022/06/15, In: Bioorganic and Medicinal Chemistry Letters. 66, 128723.Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Scopus citations
Datasets
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CCDC 1503529: Experimental Crystal Structure Determination
Mayakrishnan, S. (Creator), Arun, Y. (Creator), Balachandran, C. (Creator), Awale, S. (Creator), Maheswari, N. U. (Creator) & Perumal, P. T. (Creator), Cambridge Crystallographic Data Centre, 2017
DOI: 10.5517/ccdc.csd.cc1mgjyk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1mgjyk&sid=DataCite
Dataset
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CCDC 1959817: Experimental Crystal Structure Determination
Balakrishnan, N. (Contributor), Haribabu, J. (Contributor), Dhanabalan, A. K. (Contributor), Swaminathan, S. (Contributor), Sun, S. (Contributor), Dibwe, D. F. (Contributor), Bhuvanesh, N. (Contributor), Awale, S. (Contributor) & Karvembu, R. (Contributor), Cambridge Crystallographic Data Centre, 2019
DOI: 10.5517/ccdc.csd.cc23sbx5, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23sbx5&sid=DataCite
Dataset
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CCDC 1546968: Experimental Crystal Structure Determination
Balachandran, C. (Creator), Haribabu, J. (Creator), Jeyalakshmi, K. (Creator), Bhuvanesh, N. S. P. (Creator), Karvembu, R. (Creator), Emi, N. (Creator) & Awale, S. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1nxr6j, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nxr6j&sid=DataCite
Dataset
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CCDC 1546971: Experimental Crystal Structure Determination
Balachandran, C. (Creator), Haribabu, J. (Creator), Jeyalakshmi, K. (Creator), Bhuvanesh, N. S. P. (Creator), Karvembu, R. (Creator), Emi, N. (Creator) & Awale, S. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1nxr9m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nxr9m&sid=DataCite
Dataset
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Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5371306.v1, https://springernature.figshare.com/collections/Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/5371306/1
Dataset
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SARS-CoV-2感染によるCthrc1陽性胚線維芽細胞のBmal1転写リズムの減弱とアドレナリンによるリズム回復
Suga, K. (Speaker), Koizumi, H. (Speaker), Igarashi, M. (Speaker), Tamogami, S. (Speaker), Awale, S. (Speaker), Morioka, E. (Speaker), Yoshikawa, T. (Speaker), Yamada, H. (Speaker), Morinaga, Y. (Speaker) & Ikeda, M. (Speaker)
2024/11/16 → 2024/11/17Activity: Talk or presentation › Oral presentation
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Plants (Journal)
Awale, S. (Editor in chief)
2018 → …Activity: Publication peer-review and editorial work › Editorial work
Courses
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応用和漢医薬学特論
Watanabe, S., Tohda, C., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J. & Oku, M. 2024/12/04 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course
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臨床東西医薬学特論
Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J. & Shoji, T. 2024/04/01 → 2024/09/30
Course