Personal profile
Campus career
生命工学科（廃止） 教授 2010/04/01-2018/03/31
大学院生命融合科学教育部 部長（学部長含む） 2017/04/01-2019/03/31
工学科 教授 2018/04/01-2019/09/30
工学系 教授 2019/10/01-
工学科 教授 2019/10/01-
工学部工学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Research biography
PAC1受容体アンタゴニストの創薬研究 ライフサイエンス基礎科学研究 期間：2014/04－
SHIP2阻害剤の開発研究 共同研究 期間：2010/04－
フコシダーゼ、ラムノシダーゼ阻害剤の開発研究 共同研究 期間：2009/04－
運動学習能力を指標とした新規中枢神経作用薬 共同研究 期間：2012/04－
栄養飢餓耐性解除に基づく新規すい臓がん治療薬の開発研究 共同研究 期間：2010/04－
新規糖尿病治療薬の開発研究 共同研究 期間：2010/04－
毒ガエルアルカロイド類の合成とニコチン受容体抑制活性評価 基礎科学研究 期間：2002/04－
Qualification
Affiliated academic society
有機合成化学協会 所属期間：2000/04-
Research interests
Field of expertise (Grants-in-aid for Scientific Research classification)
- Organic chemistry
- Medical pharmacy
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性
Hosoya, K.-I. (Principal Investigator), 立川正憲 (Co-Investigator(Kenkyū-buntansha)), Toyooka, N. (Co-Investigator(Kenkyū-buntansha)) & Akanuma, S.-I. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors
Toyooka, N. (PI), Sasaoka, T. (CoI), Wada, T. (CoI) & Goda, H. H. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.
Takasaki, I. (PI), Kurihara, T. (CoI), Toyooka, N. (CoI) & Gouda, H. (CoI)
2014/04/01 → 2017/03/31
Project: Research
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Analysis of D-serine dynamics in the brain and development of novel drugs against excitotoxicity
Mori, H. (PI) & Toyooka, N. (CoI)
2013/04/01 → 2016/03/31
Project: Research
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Synthetic Studies on novel fucosidase and rhamnosidase inhibitors
Toyooka, N. (PI) & Kato, A. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models
Shintani, Y., Hayata-Takano, A., Takasaki, I., Kurihara, T., Miyata, A., Yamano, Y., Ikuta, M., Takeshita, R., Murata, K., Oguri, T., Asaka, C., Nunomura, K., Lin, B., Nakagawa, S., Okada, T., Toyooka, N., Takumi, T., Ago, Y., Takuma, K. & Hashimoto, H., 2026/02, In: Molecular Psychiatry. 31, 2, p. 1014-1026 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells
Miyamoto, Y., Hirai, W., Saka, T., Tanio, M., Kudo, Y., Yoshino, Y., Nakagawa, Y., Kobayashi, N., Takada, S., Okada, T., Toyooka, N., Kandeel, M., Tanaka, N., Ikari, A. & Endo, S., 2026/04/05, In: European Journal of Medicinal Chemistry. 307, 118649.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute toxicity of frog-skin-homologous synthetic alkaloids and frog-skin extracts: miniaturized test to evaluate toxicity with Daphnia magna
Méndez-Rivera, M., Ramírez-Morales, D., Mora-Machado, A., Pröhl, H., Rodríguez, A., Victor, V. C., Vasiliki, M. O., Okada, T., Toyooka, N., Ibáñez, R., Rodríguez-Rodríguez, C. E. & Tamayo-Castillo, G., 2025/12, In: Toxicon. 268, 108599.Research output: Contribution to journal › Article › peer-review
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Construction of trans-2,6-Disubstituted Piperidine Skeleton and Its Application to the Total Synthesis of (−)-Myrtine and trans-Piperidine-Type Poison-Frog Alkaloids
Okada, T., Eguchi, K., Hasegawa, F., Ikhlaq, M. M., Yoshikawa, T. & Toyooka, N., 2025/02/21, In: Journal of Organic Chemistry. 90, 7, p. 2749-2759 11 p.Research output: Contribution to journal › Article › peer-review
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Discovery and Structural Optimization of a Novel Serine Racemase Inhibitor with a Pyridazine Skeleton
Tozawa, C., Matsukiyo, Y., Oshima, S., Sakajiri, Y., Maeda, C., Shibata, T., Sawada, R., Okada, T., Obita, T., Mizuguchi, M., Mori, H., Yamanishi, Y. & Toyooka, N., 2025/10/06, In: ChemistrySelect. 10, 37, e05651.Research output: Contribution to journal › Article › peer-review
Datasets
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Crystal Structure of Human Serine Racemase
Takahara, S. (Contributor), Nakagawa, K. (Contributor), Uchiyama, T. (Contributor), Yoshida, T. (Contributor), Matsumoto, K. (Contributor), Kawasumi, Y. (Contributor), Mizuguchi, M. (Contributor), Obita, T. (Contributor), Watanabe, Y. (Contributor), Hayakawa, D. (Contributor), Gouda, H. (Contributor), Mori, H. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2018/01/31
DOI: 10.2210/pdb5X2L/pdb, https://www.wwpdb.org/pdb?id=pdb_00005x2l
Dataset
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Crystal structure of human transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7EJQ/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ejq
Dataset
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Crystal structure of V30M-TTR in complex with naringenin derivative-14
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9q
Dataset
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Crystal structure of V30M-TTR in complex with naringenin derivative-18
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9R/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9r
Dataset
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CCDC 1881723: Experimental Crystal Structure Determination
Takashima, K. (Creator), Hayakawa, D. (Creator), Gouda, H. (Creator) & Toyooka, N. (Creator), Cambridge Crystallographic Data Centre, 2019
DOI: 10.5517/ccdc.csd.cc2152r2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2152r2&sid=DataCite
Dataset
Prizes
Activities
- 5 Oral presentation
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Total synthesis of poison-frog alkaloids ent-cis-195A and 211A
Toyooka, N. (Speaker)
2016/09/12 → 2016/09/13Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids II
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids I
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Laboratory and practical synthesis of Suvorexant, a selective dual orexin receptor antagonist
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Synthesis of Poison-Frog Alkaloids
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
Courses
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データサイエンス特論
Movshuk, O., Fujita, Y., Chujo, D., Toyooka, N., Misawa, T., Haruki, T., Nagaoka, R. & Oku, M. 2024/10/02 → 2024/12/03
Course
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