Projects per year
Personal profile
Campus career
生命工学科(廃止) 教授 2010/04/01-2018/03/31
大学院生命融合科学教育部 部長(学部長含む) 2017/04/01-2019/03/31
工学科 教授 2018/04/01-2019/09/30
工学系 教授 2019/10/01-
工学科 教授 2019/10/01-
工学部工学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Research biography
PAC1受容体アンタゴニストの創薬研究 ライフサイエンス基礎科学研究 期間:2014/04-
SHIP2阻害剤の開発研究 共同研究 期間:2010/04-
フコシダーゼ、ラムノシダーゼ阻害剤の開発研究 共同研究 期間:2009/04-
運動学習能力を指標とした新規中枢神経作用薬 共同研究 期間:2012/04-
栄養飢餓耐性解除に基づく新規すい臓がん治療薬の開発研究 共同研究 期間:2010/04-
新規糖尿病治療薬の開発研究 共同研究 期間:2010/04-
毒ガエルアルカロイド類の合成とニコチン受容体抑制活性評価 基礎科学研究 期間:2002/04-
Qualification
Affiliated academic society
有機合成化学協会 所属期間:2000/04-
Research interests
Field of expertise (Grants-in-aid for Scientific Research classification)
- Organic chemistry
- Medical pharmacy
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 8 Finished
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Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors
Toyooka, N. (PI), Sasaoka, T. (CoI), Wada, T. (CoI) & Goda, H. H. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.
Takasaki, I. (PI), Kurihara, T. (CoI), Toyooka, N. (CoI) & Gouda, H. (CoI)
2014/04/01 → 2017/03/31
Project: Research
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Analysis of D-serine dynamics in the brain and development of novel drugs against excitotoxicity
Mori, H. (PI) & Toyooka, N. (CoI)
2013/04/01 → 2016/03/31
Project: Research
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Synthetic Studies on novel fucosidase and rhamnosidase inhibitors
Toyooka, N. (PI) & Kato, A. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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Roles of proteases and proteinase-activated receptor 2 in itching of pruritic diseases
Kuraishi, Y. (PI), Toyooka, N. (CoI), Andoh, T. (CoI), Tsujii, K. (CoI), Honma, A. (CoI), Kuwazono, T. (CoI), Mano, Y. (CoI), Takahashi, R. (CoI), Yoshida, T. (CoI), Takayama, Y. (CoI), Suzuki, K. (CoI), Kimura, Y. (CoI) & Asai, A. A. (CoI)
2011/04/01 → 2014/03/31
Project: Research
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Divergent total synthesis of indolizidine-, quinolizidine-, and decahydroquinoline-type poison-frog alkaloids
Okada, T. & Toyooka, N., 2024/01, Advances in Heterocyclic Chemistry. Scriven, E. F. V. & Ramsden, C. A. (eds.). Academic Press Inc., p. 49-88 40 p. (Advances in Heterocyclic Chemistry; vol. 144).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition
Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.Research output: Contribution to journal › Article › peer-review
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Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.Research output: Contribution to journal › Article › peer-review
5 Scopus citations
Prizes
Activities
- 5 Oral presentation
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Total synthesis of poison-frog alkaloids ent-cis-195A and 211A
Toyooka, N. (Speaker)
2016/09/12 → 2016/09/13Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids I
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Synthesis of Poison-Frog Alkaloids
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids II
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Laboratory and practical synthesis of Suvorexant, a selective dual orexin receptor antagonist
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation