Personal profile
Campus career
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Affiliated academic society
Research interests
Research Fields, Keywords
- Structural Biology
- Protein Science
- Biophysics
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 9 Finished
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自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
Mizuguchi, M. (Principal Investigator) & Obita, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Verification of the connector function of the transcription and splicing factor PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids
Kagami, A., Hashimoto, N., Sasaki, R., Fukushima, Y., Devkota, H. P., Tanaka, S., Wada, M., Yamanaka, K., Yamakawa, S., Misumi, S., Yokoyama, T., Mizuguchi, M., Sato, T., Nakamura, T., Kotani, S., Suico, M. A., Kai, H., Ueda, M. & Shuto, T., 2026/01/16, In: iScience. 29, 1, 114170.Research output: Contribution to journal › Article › peer-review
Open Access -
Catalytic Photooxygenation Demonstrates Therapeutic Efficacy in Transthyretin Amyloidosis
Yamane, M., Umeda, H., Toyobe, M., Iwai, A., Ishihara, K., Kudo, G., Mitsunuma, H., Hori, Y., Tomita, T., Mizuguchi, M., Okada, M., Ueda, M., Ando, Y., Kawashima, S. A., Sohma, Y., Kaji, H., Hirokawa, T., Yamanaka, K. & Kanai, M., 2025/08/13, In: Journal of the American Chemical Society. 147, 32, p. 28860-28874 15 p.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Development of FTase inhibitors inspired by the structures of andrastins
Kitamura, F., Tanioka, M., Kosaka, A., Matsuzawa, N., Obita, T., Sakajiri, Y., Shibata, T., Sawada, R., Yokoyama, T., Kohyama, A., Yamada, T., Yamanishi, Y., Mizuguchi, M. & Matsuya, Y., 2025/11, In: Results in Chemistry. 18, 102828.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and Structural Optimization of a Novel Serine Racemase Inhibitor with a Pyridazine Skeleton
Tozawa, C., Matsukiyo, Y., Oshima, S., Sakajiri, Y., Maeda, C., Shibata, T., Sawada, R., Okada, T., Obita, T., Mizuguchi, M., Mori, H., Yamanishi, Y. & Toyooka, N., 2025/10/06, In: ChemistrySelect. 10, 37, e05651.Research output: Contribution to journal › Article › peer-review
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Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025/01, Advances in Heterocyclic Chemistry. Scriven, E. F. V. & Ramsden, C. A. (eds.). Academic Press Inc., p. 225-261 37 p. (Advances in Heterocyclic Chemistry; vol. 147).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Datasets
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Crystal structure of DAPK1 in complex with genistein.
Yokoyama, T. (Contributor), Kosaka, Y. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2015/10/07
DOI: 10.2210/pdb5AUZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00005auz
Dataset
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Crystal structure of hemagglutinin
Kouno, T. (Contributor), Watanabe, N. (Contributor), Sakai, N. (Contributor), Nakamura, T. (Contributor), Nabeshima, Y. (Contributor), Morita, M. (Contributor), Mizuguchi, M. (Contributor), Aizawa, T. (Contributor), Demura, M. (Contributor), Imanaka, T. (Contributor), Tanaka, I. (Contributor) & Kawano, K. (Contributor), Protein Data Bank (PDB), 2010/08/11
DOI: 10.2210/pdb3A5P/pdb, https://www.wwpdb.org/pdb?id=pdb_00003a5p
Dataset
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Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6
Yokoyama, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2019/03/13
DOI: 10.2210/pdb6IMY/pdb, https://www.wwpdb.org/pdb?id=pdb_00006imy
Dataset
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Crystal structure of Human Transthyretin (wild-type)
Miyata, M. (Contributor), Sato, T. (Contributor), Mizuguchi, M. (Contributor), Nakamura, T. (Contributor), Ikemizu, S. (Contributor), Nabeshima, Y. (Contributor), Susuki, S. (Contributor), Suwa, Y. (Contributor), Morioka, H. (Contributor), Ando, Y. (Contributor), Suico, M. A. (Contributor), Shuto, T. (Contributor), Koga, T. (Contributor), Yamagata, Y. (Contributor) & Kai, H. (Contributor), Protein Data Bank (PDB), 2009/12/22
DOI: 10.2210/pdb3A4D/pdb, https://www.wwpdb.org/pdb?id=pdb_00003a4d
Dataset
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Crystal structure of H88A mutated human transthyretin
Yokoyama, T. (Contributor), Hanawa, Y. (Contributor), Obita, T. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2017/06/14
DOI: 10.2210/pdb5H0V/pdb, https://www.wwpdb.org/pdb?id=pdb_00005h0v
Dataset
Courses
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生物物理学特論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2024/12/04 → 2025/03/31
Course
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生物物理学序論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2024/10/02 → 2024/12/03
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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医療分子科学特論
Tomohiro, T., Mizuguchi, M., Yakura, T., Matsuya, Y., Obita, T., Chiba, J., Nakano, M., Ikeda, K., Lee, J., Tanimoto, H. & Okitsu, T. 2024/10/01 → 2025/03/31
Course
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