Projects per year
Personal profile
Campus career
創薬科学科 教授 2009/04/01-2019/09/30
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Affiliated academic society
日本アミロイドーシス学会 所属期間：2018/08/25-
Research interests
Structural Biology of Disease Mechanism
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fields, Keywords
- Structural Biology
- Protein Science
- Biophysics
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 8 Finished
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Verification of the connector function of the transcription and splicing factor PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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天然変性タンパク質の動的構造解析
Akashi, S. (PI), Sugase, K. (CoI), Mizuguchi, M. (CoI) & Nishimura, Y. (CoI)
2009/07/23 → 2014/03/31
Project: Research
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket
Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.Research output: Contribution to journal › Article › peer-review
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Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
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Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis
Mizuguchi, M., Obita, T., Yamada, S. & Nabeshima, Y., 2024/04, In: FEBS Journal. 291, 8, p. 1732-1743 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations