Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 助教 2010/04/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
和漢医薬学総合研究所 助教 2019/10/01-
薬学・和漢系 助教 2019/10/01-
和漢医薬学総合研究所 助教 2019/10/01-
Research interests
ピオグリタゾンは画期的な薬剤であるが,深刻な末梢性浮腫が生じることが重要な問題となっている.その対処療法として利尿薬が用いられているが,ピオグリタゾンで生じる過剰な水分の体内貯留には無効なことが多く,長期的な使用では糖尿病を悪化させる危険性が指摘されている.そのため,体内の水分代謝調節作用を持ち,電解質異常改善効果や腎保護作用を併せ持つ五苓散を用いることで末梢性浮腫を改善することが可能か否か,さらに糖尿病に対する治療効果について検討している.
Research Fields, Keywords
- pre-disease signals
- glutaminase Inhibitor
- lymphatic vessel
- Kampo
Field of expertise (Grants-in-aid for Scientific Research classification)
- General internal medicine (including psychosomatic medicine)
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Effect of goreisan on rat mesenteric lymphtic vessels.
Jo, M. (PI)
2017/04/01 → 2020/03/31
Project: Research
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Effect of Goreisan on edema improvement mechanism and expression of aquaporin 2.
Jo, M. (PI)
2013/04/01 → 2015/03/31
Project: Research
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Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles
Patel, N. A., Lui, A., Trujillo, A. N., Motawe, Z. Y., Bader, D., Schuster, J., Burgess, A., Alves, N. G., Jo, M. & Breslin, J. W., 2023/12/15, In: Life Sciences. 335, 122285.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..Research output: Contribution to journal › Article › peer-review
Activities
- 53 Oral presentation
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「伝統医薬データーベース」の構築(3)
Jo, M. (Speaker)
2013/08/31 → 2013/09/01Activity: Talk or presentation › Oral presentation
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急性創傷モデルラットに対する帰耆建中湯の黄耆増量の影響
Jo, M. (Speaker)
2013/08/31 → 2013/09/01Activity: Talk or presentation › Oral presentation
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ピオグリタゾン誘発末梢性浮腫に対する五苓散の効果に関する基礎的検討(第3報)
Jo, M. (Speaker)
2013/08/31 → 2013/09/01Activity: Talk or presentation › Oral presentation
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芎帰調血飲有効例における臨床像の検討
Jo, M. (Speaker)
2013/05/31 → 2013/06/02Activity: Talk or presentation › Oral presentation
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Effect of Goreisan on the urinary concentrating ability and the expressions of aquaporins in 5/6 nephrectomized rats
Jo, M. (Speaker)
2013/03/21 → 2013/03/23Activity: Talk or presentation › Oral presentation