The pre-disease state, which is known as Mibyou in traditional Japanese medicine (Kampo medicine), is an Oriental medical concept and has not yet been scientifically understood. In collaboration with our division and Research Center for Pre-Disease Science, University of Toyama, we are conducting research to scientifically detect the Mibyou state by analyzing the fluctuation and expression change of biometric information such as genes, proteins, and behavior during the onset process, and to clarify the biological meaning of this state. There have been marked increases in the incidence of complex diseases, such as metabolic syndrome, and it is hard to treat them using only modern medical drugs. In contrast to the symptomatic treatments offered by modern medical drugs at the disease state, drugs targeting Mibyou may have great potential advantages as preventive and preemptive medicine. Therefore, we will work on the development of the drug treatment for Mibyou, and consequently the novel medical strategies.