Projects per year
Personal profile
Campus career
医学科 教授 2005/10/01-2019/09/30
認知・情動脳科学系 教授 2006/04/01-2019/09/30
医学科 教授 2019/10/01-
医学系 教授 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
認知・情動脳科学系 教授 2006/04/01-2019/09/30
医学科 教授 2019/10/01-
医学系 教授 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Research interests
これまで,記憶・学習の分子機構解析を目的に,グルタミン酸受容体 (GluR)チャネル分子に焦点を当て,遺伝子ノックアウトマウスの作製と解析を行ってきました.その結果,GluRチャネルのサブユニットが記憶・学習,シナプス可塑性,神経回路発達,神経細胞死等に深く関わることを見出しました.また,脳内D-セリンが神経細胞で合成され,NMDA型GluRを介して神経細胞死に関わることを明らかにしました.
これからは,以下の項目の研究を進めます.
1)認知・情動・社会性の分子機構
2)生体マウス脳内での分子イメージング
3)免疫系による脳機能修飾機構の解析
これからは,以下の項目の研究を進めます.
1)認知・情動・社会性の分子機構
2)生体マウス脳内での分子イメージング
3)免疫系による脳機能修飾機構の解析
Research Fields, Keywords
- Molecular Neuroscience
Field of expertise (Grants-in-aid for Scientific Research classification)
- Neurochemistry/Neuropharmacology
Fingerprint
Dive into the research topics where Hisashi Mori is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 10 Finished
-
Analysis of D-serine dynamics for the development of new drug against neuropsychiatric disorders
Mori, H. (PI)
2018/04/01 → 2021/03/31
Project: Research
-
Neuropathology related to oligodendrocyte disorder
Sasahara, M. (PI), Mori, H. (CoI), Ishii, Y. (CoI), Yamamoto, S. (CoI), Okuno, N. (CoI) & Hamashima, T. (CoI)
2017/04/01 → 2021/03/31
Project: Research
-
Comprehensive genetic analysis of sudden unexplained death syndrome cases using a next-generation sequencing
Hata, Y. (PI), Mori, H. (CoI), Kinoshita, K. (CoI) & Nishida, N. (CoI)
2015/04/01 → 2018/03/31
Project: Research
-
-
Regulation of Arc gene transcription by SRF cofactors: mechanism and application for drug design in ASD
Tabuchi, A. (PI), Mori, H. (CoI) & Fukuchi, M. (CoI)
2014/04/01 → 2017/03/31
Project: Research
-
Cancer-associated point mutations within the extracellular domain of PTPRD affect protein stability and HSPG interaction
Matsui, Y., Tabata, A., Izumi, H., Yasumura, M., Makino, T., Shimizu, T., Sato, M., Mori, H. & Yoshida, T., 2024/04/15, In: FASEB Journal. 38, 7, e23609.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Li, L. Y., Imai, A., Izumi, H., Inoue, R., Koshidaka, Y., Takao, K., Mori, H. & Yoshida, T., 2024/12, In: Molecular Brain. 17, 1, 16.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., Hoshino, M., Nakao, A., Mori, Y., Okabe, S., Matsushita, M., Urbach, A., Katayama, Y., Matsumoto, A., Nakayama, K. I. & Katori, S. & 111 others, , 2024/03/26, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Blockade of D-serine signaling and adult hippocampal neurogenesis attenuates remote contextual fear memory following multiple memory retrievals in male mice
Inoue, R., Ni, X. & Mori, H., 2023/01/04, In: Frontiers in Neuroscience. 16, 1030702.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
2 Scopus citations