Personal profile
Campus career
薬学・和漢系 教授 2019/10/01-
和漢医薬学総合研究所 教授 2019/10/01-
Research interests
1.天然有機化合物の生合成研究
2.二次代謝酵素の立体構造解析
3.二次代謝酵素の機能改変と新規有用物質の創製
4.天然資源からの抗ウイルス,抗菌,抗がん活性化合物の単離・構造決定
Research Fields, Keywords
- Natural products
- Biosynthesis, Structre analysis
- Enzyme engineering
- Plants, Sponges
Field of expertise (Grants-in-aid for Scientific Research classification)
- Natural medicines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 12 Responsible Consumption and Production
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Collaborations and top research areas from the last five years
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神経軸索伸長活性アルカロイドの創出を指向したアルカロイド生合成酵素の機能改変
Morita, H. (Principal Investigator) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変
Morita, H. (Principal Investigator), Kodama, T. (Co-Investigator(Kenkyū-buntansha)) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Engineering of DABB-family enzymes to novel polyketide cyclase
Morita, H. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action
Gunter, N. V., Ong, Y. S., Lai, Z. W., Morita, H., Chamyuang, S., Owatworakit, A. & Mah, S. H., 2026, In: Journal of Asian Natural Products Research. 28, 2, p. 285-309 25 p.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
A New 19(10→9)Abeo-Euphane Triterpenoid with other Terpenoid Components from Trichilia dregeana Leaves and their NO Production Inhibitory Activities in LPS-Stimulated RAW264.7 Macrophages
Mba Nguekeu, Y. M., Kodama, T., Paing Htoo, Z., Matheuda, E. G., Tsepeupon Matchide, M. G., Augustin Ngouela, S., Tene, M., Ducret Awouafack, M. & Morita, H., 2025/01, In: Chemistry and Biodiversity. 22, 1, e202401919.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
A new antibacterial neo-clerodane diterpenoid and other constituents from Chasmanthera dependens Hochst. (Menispermaceae) and their chemotaxonomic significance
Ngalaha Ediah, S. H., Matheuda, E. G., Kefossang, B. A., Nguekeu, Y. M. M., Kodama, T., Hnin, S. Y. Y., Qian, Z., Awouafack, M. D., Tsopmo, A., Morita, H. & Tene, M., 2025/02, In: Biochemical Systematics and Ecology. 118, 104922.Research output: Contribution to journal › Article › peer-review
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A new ceramide and other constituents from Crinum ornatum (L.f.) Herb. (Amaryllidaceae) and their chemophenetic significance
Kouvourbe, K., Waleguele, C. C., Mba Nguekeu, Y. M., Ngouadjio Temgoua, E. V., Matheuda, E. G., Tsepeupon Matchide, M. G., Tchuente Tchuenmogne, M. A., Donfack Nanfack, A. R., Kodama, T., Anthonissen, S., Dehaen, W., Ngouela, S. A., Tene, M., Hiroyuki, M. & Awouafack, M. D., 2025/08, In: Biochemical Systematics and Ecology. 121, 104991.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Scopus citations -
Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations
Datasets
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Alkylquinolone synthase from Evodia rutaecarpa
Matsui, T. (Contributor), Kodama, T. (Contributor), Mori, T. (Contributor), Tadakoshi, T. (Contributor), Noguchi, H. (Contributor), Abe, I. (Contributor) & Morita, H. (Contributor), Protein Data Bank (PDB), 2017/04/26
DOI: 10.2210/pdb5WX4/pdb, https://www.wwpdb.org/pdb?id=pdb_00005wx4
Dataset
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CCDC 1441723: Experimental Crystal Structure Determination
Nisa, K. (Creator), Ito, T. (Creator), Kodama, T. (Creator), Tanaka, M. (Creator), Okamoto, Y. (Creator), Asakawa, Y. (Creator), Imagawa, H. (Creator) & Morita, H. (Creator), Cambridge Crystallographic Data Centre, 2016
DOI: 10.5517/cc1kd76d, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1kd76d&sid=DataCite
Dataset
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CCDC 674018: Experimental Crystal Structure Determination
Morita, H. (Creator), Oida, Y. (Creator), Ariga, T. (Creator), Fukumoto, S. (Creator), Sheikh, M. C. (Creator), Fujii, T. (Creator) & Yoshimura, T. (Creator), Cambridge Crystallographic Data Centre, 2011
DOI: 10.5517/ccqmcj6, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccqmcj6&sid=DataCite
Dataset
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Polyketide cyclase OAC from Cannabis sativa, Y72F mutant
Yang, X. (Contributor), Matsui, T. (Contributor), Kodama, T. (Contributor), Mori, T. (Contributor), Zhou, X. (Contributor), Taura, F. (Contributor), Noguchi, H. (Contributor), Abe, I. (Contributor) & Morita, H. (Contributor), Protein Data Bank (PDB), 2016/01/27
DOI: 10.2210/pdb5B0F/pdb, https://www.wwpdb.org/pdb?id=pdb_00005b0f
Dataset
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Crystal structure of the indole prenyltransferase TleC apo structure
Mori, T. (Contributor), Zhang, L. (Contributor), Awakawa, T. (Contributor), Hoshino, S. (Contributor), Okada, M. (Contributor), Morita, H. (Contributor) & Abe, I. (Contributor), Protein Data Bank (PDB), 2016/03/16
DOI: 10.2210/pdb4YZK/pdb, https://www.wwpdb.org/pdb?id=pdb_00004yzk
Dataset
Prizes
Activities
- 50 Oral presentation
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Biosynthesis of 2-alkylquinolone in the medicinal plant Evodia rutaecarpa
Morita, H. (Speaker)
2018/11/05Activity: Talk or presentation › Oral presentation
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Preferential cytotoxic constituents from Aframomum melegueta against human pancreatic cancer cell line
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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ヒメハギ科植物Securidaca longepedunculataより単離されたMuchimangin類の合成研究
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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芳香族ドデカケタイドを生産する機能改変型アロエ由来Ⅲ型ポリケタイド合成酵素のX線結晶構造解析
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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放線菌由来新規インドールプレニルトランスフェラーゼTldCとMpnDの機能解析
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
Courses
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応用和漢医薬学特論
Watanabe, S., Tohda, C., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J. & Oku, M. 2024/12/04 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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国際医薬学特論
Hosoya, K.-I., Tomohiro, T., Sakai, H., Tabuchi, A., Hirose, Y., Nitta, A., Matsuya, Y., Shimizu, T., Chiba, J., Fujii, T., Kume, T., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S. & Nakagawa, Y. 2024/10/01 → 2025/03/31
Course