Atsushi Kato

2025

Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-L-rhamnosidase: Design, synthesis and structure-activity relationship study

Gao, F.-T., Zhang, M., Shimadate, Y., Kato, A., Li, Y.-X., Jia, Y.-M. & Yu, C.-Y., 2025/01/01, In: European Journal of Medicinal Chemistry. 282, p. 117031

Research output: Contribution to journal › Article › peer-review

2024

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives

Gao, F.-T., Wu, Q.-K., Zhang, M., Shimadate, Y., Qian, G., Song, Y.-Y., Kato, A., Li, Y.-X., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2024/06/06, (E-pub ahead of print) In: European Journal of Medicinal Chemistry. 275, p. 116570

Research output: Contribution to journal › Article › peer-review

Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition

Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Thioarylation of 6-Amino-2,3,6-trideoxy-d-manno-oct-2-ulosonic Acid (IminoKdo): Access to 3,6-Disubstituted Picolinates and Mechanistic Insights

Manmode, S., Hussain, N., Marin, O. J. G., Kato, A., Veytia-Bucheli, J. I., Vincent, S. P. & Gauthier, C., 2024/02/26, In: Chemistry - A European Journal. 30, 12, p. e202303904

Research output: Contribution to journal › Article › peer-review

2023

Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches

Zi, D., Shimadate, Y., Wang, J.-Z., Kato, A., Li, Y.-X., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2023/03/29, In: Organic and Biomolecular Chemistry. 21, 13, p. 2729-2741 13 p.

Research output: Contribution to journal › Article › peer-review

Design and pharmacological chaperone effects of N-(4'-phenylbutyl)-DAB derivatives targeting the lipophilic pocket of lysosomal acid α-glucosidase

Kato, A., Nakagome, I., Kise, M., Yoshimura, K., Tanaka, N., Nash, R. J., Fleet, G. W. J., Kobayashi, Y., Ikeda, H., Okada, T. & Toyooka, N., 2023/07/13, In: Journal of Medicinal Chemistry. 66, 13, p. 9023-9039 17 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase

Yang, L.-F., Zhang, M., Shimadate, Y., Kato, A., Hou, T.-Y. L., Li, Y.-X., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2023/04/26, In: Organic and Biomolecular Chemistry. 21, 16, p. 3453-3464 12 p.

Research output: Contribution to journal › Article › peer-review

Erratum: Characterizing the selectivity of ER α-glucosidase inhibitors (Glycobiology (2019) 29:7 (530-542) DOI: 10.1093/glycob/cwz029)

O'Keefe, S., Roebuck, Q. P., Nakagome, I., Hirono, S., Kato, A., Nash, R. & High, S., 2023/06/01, In: Glycobiology. 33, 6, p. 525 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

Désiré, J., Debbah, Z., Gueyrard, D., Marrot, J., Blériot, Y. & Kato, A., 2023/07/25, (E-pub ahead of print) In: Carbohydrate Research. 532, p. 108903

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives

Zi, D., Song, Y. Y., Lu, T. T., Kise, M., Kato, A., Wang, J. Z., Jia, Y. M., Li, Y. X., Fleet, G. W. J. & Yu, C. Y., 2023/02/05, In: European Journal of Medicinal Chemistry. 247, 115056.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Synthesis of the purported structure of glyphaeaside C and proposed revisions to the structures of the glyphaeaside alkaloids

Byatt, B. J., Kato, A. & Pyne, S. G., 2023/05/26, In: Journal of Natural Products. 86, 5, p. 1261-1273 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2022

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Translated title of the contribution: 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe DiseaseKato, A., Nakagome, I., Kanekiyo, U., Lu, T.-T., Li, Y.-X., Yoshimura, K., Kishida, M., Shinzawa, K., Yoshida, T., Tanaka, N., Jia, Y.-M., Nash, R. J., Fleet, G. W. J. & Yu, C.-Y., 2022/02/10, In: Journal of Medicinal Chemistry. 65, 3, p. 2329-2341 13 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy

Campkin, D. M., Shimadate, Y., Bartholomew, B., Bernhardt, P. V., Nash, R. J., Sakoff, J. A., Kato, A. & Simone, M. I., 2022/06/01, In: Molecules. 27, 11, 3447.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study

Li, Y.-X., Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2022/12/15, In: European Journal of Medicinal Chemistry. 244, p. 114852

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives

Translated title of the contribution: Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivativesWang, J.-Z., Cheng, B., Kato, A., Kise, M., Shimadate, Y., Jia, Y.-M., Li, Y.-X., Fleet, G. W. J. & Yu, C.-Y., 2022/04, In: European Journal of Medicinal Chemistry. 233, p. 114230-114230 1 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives

Translated title of the contribution: Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine DerivativesLi, Y.-X., Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2022/06/03, In: Journal of Organic Chemistry. 87, 11, p. 7291-7307 17 p.

Research output: Contribution to journal › Article

8 Scopus citations

Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.

Translated title of the contribution: Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.Takashima, K., Okada, T., Kato, A., Yamasaki, Y., Sugouchi, T., Akanuma, S.-I., Kubo, Y., Hosoya, K.-I., Morita, H., Ito, T., Kodama, T., Tanabe, G. & Toyooka, N., 2022/02, In: ChemistrySelect. 7, 5

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

Olajide, O. A., Iwuanyanwu, V. U., Banjo, O. W., Kato, A., Penkova, Y. B., Fleet, G. W. J. & Nash, R. J., 2022/05/01, In: Molecules. 27, 10, 3342.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation

Kato, A., Nakagome, I., Yoshimura, K., Kanekiyo, U., Kishida, M., Shinzawa, K., Lu, T.-T., Li, Y.-X., Nash, R. J., Fleet, G. W. J., Tanaka, N. & Yu, C.-Y., 2022/09/28, In: Organic and Biomolecular Chemistry. 20, p. 7250 7260 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic β-amino acids

Balo, R., Fernández, A. G., Chopdat, A., Ayadi, S. E., Kato, A., Estévez, R. J., Fleet, G. W. J. & Estévez, J. C., 2022/12/07, In: Organic and Biomolecular Chemistry. 20, 47, p. 9447-9459 13 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors

Translated title of the contribution: Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitorsBouquet, J., Auberger, N., Ashmus, R., King, D., Bordes, A., Fontelle, N., Nakagawa, S., Madden, Z., Proceviat, C., Kato, A., Désiré, J., Vocadlo, D. J. & Blériot, Y., 2022/01, In: Organic and Biomolecular Chemistry. 20, 3, p. 619-629 11 p.

Research output: Contribution to journal › Article

4 Scopus citations

Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif

Désiré, J., Foucart, Q., Poveda, A., Gourlaouen, G., Shimadate, Y., Kise, M., Proceviat, C., Ashmus, R., Vocadlo, D. J., Jiménez-Barbero, J., Kato, A. & Blériot, Y., 2022/01, In: Carbohydrate Research. 511, 108491.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease

Wang, J. Z., Shimadate, Y., Kise, M., Kato, A., Jia, Y. M., Li, Y. X., Fleet, G. W. J. & Yu, C. Y., 2022/08/05, In: European Journal of Medicinal Chemistry. 238, 114499.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2021

Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G₀/G₁ cell cycle arrest

Shinzawa, K., Kageta, D., Nash, R. J., Fleet, G. W. J., Imahori, T. & Kato, A., 2021/04/09, In: Tetrahedron. 85, 132077.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease**

Zhu, S., Jagadeesh, Y., Tran, A. T., Imaeda, S., Boraston, A., Alonzi, D. S., Poveda, A., Zhang, Y., Désiré, J., Charollais-Thoenig, J., Demotz, S., Kato, A., Butters, T. D., Jiménez-Barbero, J., Sollogoub, M. & Blériot, Y., 2021/08/05, In: Chemistry - A European Journal. 27, 44, p. 11291-11297 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-diepi-stereoisomers

Translated title of the contribution: Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-diepi-stereoisomersLi, Y.-X., Wang, J.-Z., Kato, A., Shimadate, Y., Kise, M., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2021/11, In: Organic and Biomolecular Chemistry. 19, 43, p. 9410-9420 11 p.

Research output: Contribution to journal › Article

9 Scopus citations

Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Bordes, A., Poveda, A., Fontelle, N., Ardá, A., Guillard, J., Ruan, Y. B., Marrot, J., Imaeda, S., Kato, A., Désiré, J., Xie, J., Jiménez-Barbero, J. & Blériot, Y., 2021/03, In: Carbohydrate Research. 501, 108258.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ derivatives

Lu, T. T., Shimadate, Y., Cheng, B., Kanekiyo, U., Kato, A., Wang, J. Z., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2021/11/15, In: European Journal of Medicinal Chemistry. 224, 113716.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Synthesis and Structural Revision of Glyphaeaside C

Byatt, B. J., Kato, A. & Pyne, S. G., 2021/05/21, In: Organic Letters. 23, 10, p. 4029-4033 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

セラミド含量増加剤

Kato, A. (Inventor), Ishikawa, F. (Inventor) & Miura, D. (Inventor), 2021/01/29, Patent No. 6830580

Research output: Industrial property › Patent

セラミド調整剤

Kato, A. (Inventor) & Ishikawa, F. (Inventor), 2021/09/24, Patent No. 6948654

Research output: Industrial property › Patent

2020

A divergent entry to 1,2,3,9-tetrahydroxyquinolizidines

Okada, T., Ozaki, T., Kato, A., Adachi, I. & Toyooka, N., 2020/06/18, In: Tetrahedron Letters. 61, 25, 152030.

Research output: Contribution to journal › Article › peer-review

Open Access

Erratum: Total synthesis of natural hyacinthacine C5 and six related hyacinthacine C5 epimers (The Journal of Organic Chemistry (2018) 83:10 (5558-5576) DOI: 10.1021/acs.joc.8b00585)

Carroll, A. W., Savaspun, K., Willis, A. C., Hoshino, M., Kato, A. & Pyne, S. G., 2020/05/01, In: Journal of Organic Chemistry. 85, 9, p. 6242 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Erratum: Corrected Structure of Natural Hyacinthacine C₁ via Total Synthesis (Journal of Natural Products (2019) 82: 2 (358−367) DOI: 10.1021/acs.jnatprod.8b00879)

Carroll, A. W., Willis, A. C., Hoshino, M., Kato, A. & Pyne, S. G., 2020/05/22, In: Journal of Natural Products. 83, 5, p. 1733 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Hanessian-Hullar reaction in the synthesis of highly substituted trans-3,4-dihydroxypyrrolidines: Rhamnulose iminosugar mimics inhibit α-glucosidase

Liu, Z., Yoshihara, A., Jenkinson, S. F., Wormald, M. R., Kelly, C., Heap, J. T., Marqvorsen, M. H. S., Estévez, R. J., Fleet, G. W. J., Nakagawa, S., Izumori, K., Nash, R. J. & Kato, A., 2020/01/03, In: Tetrahedron. 76, 1, 130758.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity

Kato, A., Nakagome, I., Hata, M., Nash, R. J., Fleet, G. W. J., Natori, Y., Yoshimura, Y., Adachi, I. & Hirono, S., 2020/06, In: Molecules. 25, 12, 2843.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Synthesis and glycosidase inhibition of: N-substituted derivatives of 1,4-dideoxy-1,4-imino-d-mannitol (DIM)

Yang, L. F., Shimadate, Y., Kato, A., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2020, In: Organic and Biomolecular Chemistry. 18, 5, p. 999-1011 13 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease

Martínez-Bailén, M., Carmona, A. T., Cardona, F., Matassini, C., Goti, A., Kubo, M., Kato, A., Robina, I. & Moreno-Vargas, A. J., 2020/04/15, In: European Journal of Medicinal Chemistry. 192, 112173.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Synthesis of pyrrolidine monocyclic analogues of pochonicine and its stereoisomers: Pursuit of simplified structures and potent β-N-acetylhexosaminidase inhibition

Yan, X., Shimadate, Y., Kato, A., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2020, In: Molecules. 25, 7, 1498.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Bi(OTf) ₃ -mediated intramolecular epoxide opening for bicyclic azepane synthesis

Zhu, S., Tran, A. T., Hirokami, Y., Gontard, G., Khaled, O., Zhang, Y., Kato, A., Blériot, Y. & Sollogoub, M., 2019/02/12, In: Journal of Carbohydrate Chemistry. 38, 2, p. 139-149 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Catalytic asymmetric synthesis of stereoisomers of 1-C-n-butyl-LABs for the SAR study of α-glucosidase inhibition

Natori, Y., Sakuma, T., Watanabe, H., Wakamatsu, H., Kato, A., Adachi, I., Takahata, H. & Yoshimura, Y., 2019/05/17, In: Tetrahedron. 75, 20, p. 2866-2876 11 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Chain-Branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases

Estévez, J. C., González, M. A., Carmen Villaverde, M., Hirokami, Y., Kato, A., Sussman, F., Reza, D. & Estévez, R. J., 2019/06, In: Pharmaceuticals. 12, 2, 47.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Characterizing the selectivity of ER α-glucosidase inhibitors

O'Keefe, S., Roebuck, Q. P., Nakagome, I., Hirono, S., Kato, A., Nash, R. & High, S., 2019/07/01, In: Glycobiology. 29, 7, p. 530-542 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Corrected structure of natural hyacinthacine c₁ via total synthesis

Carroll, A. W., Willis, A. C., Hoshino, M., Kato, A. & Pyne, S. G., 2019/02/22, In: Journal of Natural Products. 82, 2, p. 358-367 10 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Effect of kamikihito on platelet count: Retrospective pilot study

Nogami, T., Kato, A., Ishikawa, Y., Ryu, N. & Adachi, I., 2019/12/01, In: Traditional & Kampo Medicine. 6, 3, p. 130-133 4 p.

Research output: Contribution to journal › Article › peer-review

Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition

Martínez-Bailén, M., Carmona, A. T., Patterson-Orazem, A. C., Lieberman, R. L., Ide, D., Kubo, M., Kato, A., Robina, I. & Moreno-Vargas, A. J., 2019/05, In: Bioorganic Chemistry. 86, p. 652-664 13 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes

Kato, A., Koyama, J., Shinzawa, K., Imaeda, S., Adachi, I., Nash, R. J., Fleet, G. W. J., Shintani, M., Takeuchi, C. & Ishikawa, F., 2019/06/01, In: Bioorganic and Medicinal Chemistry. 27, 11, p. 2172-2180 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids

Martínez, R. F., Jenkinson, S. F., Nakagawa, S., Kato, A., Wormald, M. R., Fleet, G. W. J., Hollinshead, J. & Nash, R. J., 2019/07/01, In: Amino Acids. 51, 7, p. 991-998 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Synthesis and glycosidase inhibition of broussonetine M and its analogues

Wu, Q. K., Kinami, K., Kato, A., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2019/10/15, In: Molecules. 24, 20, 3712.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C -allyl iminosugar

Foucart, Q., Shimadate, Y., Marrot, J., Kato, A., Désiré, J. & Blériot, Y., 2019, In: Organic and Biomolecular Chemistry. 17, 30, p. 7204-7214 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Atsushi Kato

Research output

Search results