International IR / Security Export Control Division, Organization for International Education and Exchange

2024

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., Hoshino, M., Nakao, A., Mori, Y., Okabe, S., Matsushita, M., Urbach, A., Katayama, Y., Matsumoto, A., Nakayama, K. I. & Katori, S. & 111 others, Sato, T., Iwasato, T., Nakamura, H., Goshima, Y., Raveau, M., Tatsukawa, T., Yamakawa, K., Takahashi, N., Kasai, H., Inazawa, J., Nobuhisa, I., Kagawa, T., Taga, T., Darwish, M., Nishizono, H., Takao, K., Sapkota, K., Nakazawa, K., Takagi, T., Fujisawa, H., Sugimura, Y., Yamanishi, K., Rajagopal, L., Hannah, N. D., Meltzer, H. Y., Yamamoto, T., Wakatsuki, S., Araki, T., Tabuchi, K., Numakawa, T., Kunugi, H., Huang, F. L., Hayata-Takano, A., Hashimoto, H., Tamada, K., Takumi, T., Kasahara, T., Kato, T., Graef, I. A., Crabtree, G. R., Asaoka, N., Hatakama, H., Kaneko, S., Kohno, T., Hattori, M., Hoshiba, Y., Miyake, R., Obi-Nagata, K., Hayashi-Takagi, A., Becker, L. J., Yalcin, I., Hagino, Y., Kotajima-Murakami, H., Moriya, Y., Ikeda, K., Kim, H., Kaang, B. K., Otabi, H., Yoshida, Y., Toyoda, A., Komiyama, N. H., Grant, S. G. N., Ida-Eto, M., Narita, M., Matsumoto, K. I., Okuda-Ashitaka, E., Ohmori, I., Shimada, T., Yamagata, K., Ageta, H., Tsuchida, K., Inokuchi, K., Sassa, T., Kihara, A., Fukasawa, M., Usuda, N., Katano, T., Tanaka, T., Yoshihara, Y., Igarashi, M., Hayashi, T., Ishikawa, K., Yamamoto, S., Nishimura, N., Nakada, K., Hirotsune, S., Egawa, K., Higashisaka, K., Tsutsumi, Y., Nishihara, S., Sugo, N., Yagi, T., Ueno, N., Yamamoto, T., Kubo, Y., Ohashi, R., Shiina, N., Shimizu, K., Higo-Yamamoto, S., Oishi, K., Mori, H., Furuse, T., Tamura, M., Shirakawa, H., Sato, D. X., Inoue, Y. U., Inoue, T., Komine, Y., Yamamori, T., Sakimura, K. & Miyakawa, T., 2024/03/26, In: eLife. 12

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2023

Action potential firing rhythms in the suprachiasmatic nucleus of the diurnal grass rat, Arvicanthis niloticus

Morioka, E., Miyamoto, T., Tamogami, S., Koketsu, T., Kim, J., Yoshikawa, T., Mochizuki, T. & Ikeda, M., 2023/01/01, In: Neuroscience Letters. 792, 136954.

Research output: Contribution to journal › Article › peer-review

Open Access

Cold-induced suspension and resetting of Ca²⁺ and transcriptional rhythms in the suprachiasmatic nucleus neurons

Enoki, R., Kon, N., Shimizu, K., Kobayashi, K., Hiro, S., Chang, C. P., Nakane, T., Ishii, H., Sakamoto, J., Yamaguchi, Y. & Nemoto, T., 2023/12/15, In: iScience. 26, 12, 108390.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates

Shimizu, K., Inoue, K. I., Oishi, T., Takada, M., Fukada, Y. & Imai, H., 2023/12, In: Molecular Brain. 16, 1, 31.

Research output: Contribution to journal › Article › peer-review

Open Access

Sleep disturbance after cessation of cannabis administration in mice

Asano, T., Takemoto, H., Horita, T., Tokutake, T., Izuo, N., Mochizuki, T. & Nitta, A., 2023/12, In: Neuropsychopharmacology Reports. 43, 4, p. 505-512 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity

Takeuchi, S., Shimizu, K., Fukada, Y. & Emoto, K., 2023/12, In: Communications Biology. 6, 1, 332.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2020

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Saito, R., Koebis, M., Nagai, T., Shimizu, K., Liao, J., Wulaer, B., Sugaya, Y., Nagahama, K., Uesaka, N., Kushima, I., Mori, D., Maruyama, K., Nakao, K., Kurihara, H., Yamada, K., Kano, M., Fukada, Y., Ozaki, N. & Aiba, A., 2020/12/01, In: Translational Psychiatry. 10, 1, 35.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice

Mahoney, C. E., Mochizuki, T. & Scammell, T. E., 2020/06/01, In: Sleep. 43, 6, p. 1-17 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Hippocampal 7α-Hydroxylated Neurosteroids Are Raised by Training and Bolster Remote Spatial Memory with Increase of the Spine Densities

Maehata, K., Shimizu, K., Ikeno, T., Wang, Q., Sakurai, A., Wei, Z., Pan, Y., Takao, T. & Fukada, Y., 2020/10/23, In: iScience. 23, 10, 101559.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Intracellular interplay between cholecystokinin and leptin signalling for satiety control in rats

Koizumi, H., Mohammad, S., Ozaki, T., Muto, K., Matsuba, N., Kim, J., Pan, W., Morioka, E., Mochizuki, T. & Ikeda, M., 2020/12/01, In: Scientific Reports. 10, 1, 12000.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids

Wang, Q., Shimizu, K., Maehata, K., Pan, Y., Sakurai, K., Hikida, T., Fukada, Y. & Takao, T., 2020/04, In: Journal of Lipid Research. 61, 4, p. 570-579 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

Yamaguchi, H., Honda, S., Torii, S., Shimizu, K., Katoh, K., Miyake, K., Miyake, N., Fujikake, N., Sakurai, H. T., Arakawa, S. & Shimizu, S., 2020/12/01, In: Nature Communications. 11, 1, 5311.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2019

Reassessing the role of histaminergic tuberomammillary neurons in arousal control

Venner, A., Mochizuki, T., Luca, R. D., Anaclet, C., Scammell, T. E., Saper, C. B., Arrigoni, E. & Fuller, P. M., 2019/11/06, In: Journal of Neuroscience. 39, 45, p. 8929-8939 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2017

Descending projections from the basal forebrain to the orexin neurons in mice

Agostinelli, L. J., Ferrari, L. L., Mahoney, C. E., Mochizuki, T., Lowell, B. B., Arrigoni, E. & Scammell, T. E., 2017/05/01, In: Journal of Comparative Neurology. 525, 7, p. 1668-1684 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Histamine N-methyltransferase regulates aggression and the sleep-wake cycle

Naganuma, F., Nakamura, T., Yoshikawa, T., Iida, T., Miura, Y., Kárpáti, A., Matsuzawa, T., Yanai, A., Mogi, A., Mochizuki, T., Okamura, N. & Yanai, K., 2017/12/01, In: Scientific Reports. 7, 1, 15899.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice

Shimizu, K. & Fukada, Y., 2017/06/20, In: Bio-protocol. 7, 12, p. e2346

Research output: Contribution to journal › Article › peer-review

2016

SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior

Nakano, J. J., Shimizu, K., Shimba, S. & Fukada, Y., 2016/09/19, In: Scientific Reports. 6, 33500.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory

Shimizu, K., Kobayashi, Y., Nakatsuji, E., Yamazaki, M., Shimba, S., Sakimura, K. & Fukada, Y., 2016/09/30, In: Nature Communications. 7, 12926.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

2014

Acute enhancement of non-rapid eye movement sleep in rats after drinking water contaminated with cadmium chloride

Unno, K., Yamoto, K., Takeuchi, K., Kataoka, A., Ozaki, T., Mochizuki, T., Honda, K., Miura, N. & Ikeda, M., 2014/02, In: Journal of Applied Toxicology. 34, 2, p. 205-213 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms

Kon, N., Yoshikawa, T., Honma, S., Yamagata, Y., Yoshitane, H., Shimizu, K., Sugiyama, Y., Hara, C., Kameshita, I., Honma, K. I. & Fukada, Y., 2014, In: Genes and Development. 28, 10, p. 1101-1110 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2013

Amygdala lesions reduce cataplexy in orexin knock-out mice

Burgess, C. R., Oishi, Y., Mochizuki, T., Peever, J. H. & Scammell, T. E., 2013, In: Journal of Neuroscience. 33, 23, p. 9734-9742 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice

Kantor, S., Mochizuki, T., Lops, S. N., Ko, B., Clain, E., Clark, E., Yamamoto, M. & Scammell, T. E., 2013/08/01, In: Sleep. 36, 8, p. 1129-1138 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Role of the medial prefrontal cortex in cataplexy

Oishi, Y., Williams, R. H., Agostinelli, L., Arrigoni, E., Fuller, P. M., Mochizuki, T., Saper, C. B. & Scammell, T. E., 2013, In: Journal of Neuroscience. 33, 23, p. 9743-9751 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

2011

Hcrtr1 and 2 signaling differentially regulates depression-like behaviors

Scott, M. M., Marcus, J. N., Pettersen, A., Birnbaum, S. G., Mochizuki, T., Scammell, T. E., Nestler, E. J., Elmquist, J. K. & Lutter, M., 2011/09/23, In: Behavioural Brain Research. 222, 2, p. 289-294 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

113 Scopus citations

Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

Mochizuki, T., Arrigoni, E., Marcus, J. N., Clark, E. L., Yamamoto, M., Honer, M., Borroni, E., Lowell, B. B., Elmquist, J. K. & Scammell, T. E., 2011/03/15, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4471-4476 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex

Yamasaki, T., Kawasaki, H., Arakawa, S., Shimizu, K., Shimizu, S., Reiner, O., Okano, H., Nishina, S., Azuma, N., Penninger, J. M., Katada, T. & Nishina, H., 2011/11/16, In: Journal of Neuroscience. 31, 46, p. 16872-16883 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2010

Abnormal sleep/wake dynamics in orexin knockout mice

Diniz Behn, C. G., Klerman, E. B., Mochizuki, T., Lin, S. C. & Scammell, T. E., 2010/03/01, In: Sleep. 33, 3, p. 297-306 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Activation of the basal forebrain by the orexin/hypocretin neurones

Arrigoni, E., Mochizuki, T. & Scammell, T. E., 2010/03, In: Acta Physiologica. 198, 3, p. 223-235 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

2009

Feeding-elicited cataplexy in orexin knockout mice

Clark, E. L., Baumann, C. R., Cano, G., Scammell, T. E. & Mochizuki, T., 2009/07/21, In: Neuroscience. 161, 4, p. 970-977 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Orexin neurons are necessary for the circadian control of REM sleep

Kantor, S., Mochizuki, T., Janisiewicz, A. M., Clark, E., Nishino, S. & Scammell, T. E., 2009/09/01, In: Sleep. 32, 9, p. 1127-1134 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

2008

Delayed orexin signaling consolidates wakefulness and sleep: Physiology and modeling

Diniz Behn, C. G., Kopell, N., Brown, E. N., Mochizuki, T. & Scammell, T. E., 2008/06, In: Journal of Neurophysiology. 99, 6, p. 3090-3103 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Gene expression in the rat brain during prostaglandin D₂ and adenosinergically-induced sleep

Terao, A., Huang, Z. L., Wisor, J. P., Mochizuki, T., Gerashchenko, D., Urade, Y. & Kilduff, T. S., 2008/05, In: Journal of Neurochemistry. 105, 4, p. 1480-1498 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Neural circuitry of stress-induced insomnia in rats

Cano, G., Mochizuki, T. & Saper, C. B., 2008/10/01, In: Journal of Neuroscience. 28, 40, p. 10167-10184 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

204 Scopus citations

Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: Changes in the sleep-wake stages and electroencephalographic power spectra

Shea, J. L., Mochizuki, T., Sagvaag, V., Aspevik, T., Bjorkum, A. A. & Datta, S., 2008/06/05, In: Brain Research. 1213, p. 48-56 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats

Cui, Y., Kataoka, Y., Inui, T., Mochizuki, T., Onoe, H., Matsumura, K., Urade, Y., Yamada, H. & Watanabe, Y., 2008/03, In: Journal of Neuroscience Research. 86, 4, p. 929-936 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2007

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Lazarus, M., Yoshida, K., Coppari, R., Bass, C. E., Mochizuki, T., Lowell, B. B. & Saper, C. B., 2007/09, In: Nature Neuroscience. 10, 9, p. 1131-1133 3 p.

Research output: Contribution to journal › Article › peer-review

286 Scopus citations

microRNA Modulation of Circadian-Clock Period and Entrainment

Cheng, H. Y. M., Papp, J. W., Varlamova, O., Dziema, H., Russell, B., Curfman, J. P., Nakazawa, T., Shimizu, K., Okamura, H., Impey, S. & Obrietan, K., 2007/06/07, In: Neuron. 54, 5, p. 813-829 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

504 Scopus citations

Proteolytic Degradation of SCOP in the Hippocampus Contributes to Activation of MAP Kinase and Memory

Shimizu, K., Phan, T., Mansuy, I. M. & Storm, D. R., 2007/03/23, In: Cell. 128, 6, p. 1219-1229 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Running promotes wakefulness and increases cataplexy in orexin knockout mice

España, R. A., McCormack, S. L., Mochizuki, T. & Scammell, T. E., 2007/11/01, In: Sleep. 30, 11, p. 1417-1425 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

2006

Altered sleep-wake characteristics and lack of arousal response to H ₃ receptor antagonist in histamine H₁ receptor knockout mice

Huang, Z. L., Mochizuki, T., Qu, W. M., Hong, Z. Y., Watanabe, T., Urade, Y. & Hayaishi, O., 2006/03/21, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4687-4692 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

165 Scopus citations

Elevated body temperature during sleep in orexin knockout mice

Mochizuki, T., Klerman, E. B., Sakurai, T. & Scammell, T. E., 2006, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 3, p. R533-R540

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2005

Thalamic Ca_v3.1 T-type Ca²⁺ channel plays a crucial role in stabilizing sleep

Anderson, M. P., Mochizuki, T., Xie, J., Fischler, W., Manger, J. P., Talley, E. M., Scammell, T. E. & Tonegawa, S., 2005/02/01, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 5, p. 1743-1748 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

2004

Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D₂

Qu, W. M., Huang, Z. L., Mochizuki, T., Eguchi, N., Chen, J. F., Schwarzschild, M. A., Fink, S. J., Urade, Y. & Hayaishi, O., 2004/05, In: Sleep and Biological Rhythms. 2, SUPPL. 1, p. S55

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Behavioral state instability in orexin knockout mice

Scammell, T. E., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Mochizuki, T., 2004/05, In: Sleep and Biological Rhythms. 2, SUPPL. 1, p. S13-S14

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Behavioral state instability in orexin knock-out mice

Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T. & Scammell, T. E., 2004/07/14, In: Journal of Neuroscience. 24, 28, p. 6291-6300 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

331 Scopus citations

Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E₂ and D₂

Huang, Z. L., Qu, W. M., Eguchi, N., Chu, M., Okada, T., Sato, Y., Sakata, M., Mochizuki, T., Urade, Y. & Hayaishi, O., 2004/05, In: Sleep and Biological Rhythms. 2, SUPPL. 1, p. S21-S22

Research output: Contribution to journal › Article › peer-review

Isoform-Specific Knockout of FE65 Leads to Impaired Learning and Memory

Wang, B., Hu, Q., Hearn, M. G., Shimizu, K., Ware, C. B., Liggitt, D. H., Jin, L. W., Cool, B. H., Storm, D. R. & Martin, G. M., 2004/01/01, In: Journal of Neuroscience Research. 75, 1, p. 12-24 13 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

2003

Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep

Okada, T., Mochizuki, T., Huang, Z. L., Eguchi, N., Sugita, Y., Urade, Y. & Hayaishi, O., 2003/12/05, In: Biochemical and Biophysical Research Communications. 312, 1, p. 29-34 6 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Prostaglandin E₂ activates the histaminergic system via the EP₄ receptor to induce wakefulness in rats

Huang, Z. L., Sato, Y., Mochizuki, T., Okada, T., Qu, W. M., Yamatodani, A., Urade, Y. & Hayaishi, O., 2003/07/09, In: Journal of Neuroscience. 23, 14, p. 5975-5983 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway

Shimizu, K., Okada, M., Nagai, K. & Fukada, Y., 2003/04/25, In: Journal of Biological Chemistry. 278, 17, p. 14920-14925 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

International IR / Security Export Control Division, Organization for International Education and Exchange

Research output

Search results